Consorzio Mario Negri Sud, Via Nazionale, Santa Maria Imbaro (Chieti) 66030, Italy.
Biochem J. 2011 Jan 1;433(1):1-9. doi: 10.1042/BJ20101058.
Remarkable advances have been made during the last few decades in defining the organizational principles of the secretory pathway. The Golgi complex in particular has attracted special attention due to its central position in the pathway, as well as for its fascinating and complex structure. Analytical studies of this organelle have produced significant advances in our understanding of its function, although some aspects still seem to elude our comprehension. In more recent years a level of complexity surrounding this organelle has emerged with the discovery that the Golgi complex is involved in cellular processes other than the 'classical' trafficking and biosynthetic pathways. The resulting picture is that the Golgi complex can be considered as a cellular headquarters where cargo sorting/processing, basic metabolism, signalling and cell-fate decisional processes converge.
在过去的几十年中，人们在定义分泌途径的组织原则方面取得了显著的进展。高尔基体复合体因其在途径中的中心位置以及其迷人而复杂的结构而受到特别关注。对这个细胞器的分析研究极大地促进了我们对其功能的理解，尽管有些方面似乎仍然难以理解。近年来，随着发现高尔基体复合体参与除了“经典”运输和生物合成途径之外的细胞过程，围绕这个细胞器的复杂程度出现了一个新的层面。由此产生的图像是，高尔基体复合体可以被认为是一个细胞总部，其中货物分拣/加工、基础代谢、信号和细胞命运决策过程汇聚在一起。
