Zhu Wenhao, Wang Qiwang, Xu Liye, Yang Xiaoying, Lei Yu
Department of Rheumatology and Immunology, Zhengzhou Gout Rheumatism Hospital, Zhengzhou, 450015, China.
Department of Rheumatology and Immunology, Kunming BoGu Rheumatism Hospital, Kunming, 650506, China.
Clin Rheumatol. 2025 Jan;44(1):67-80. doi: 10.1007/s10067-024-07252-4. Epub 2024 Nov 29.
Studies have shown inconsistent results regarding the effects of tea drinking on serum uric acid (SUA) and hyperuricemia (HUA). Therefore, a meta-analysis was conducted to assess the association between tea drinking and SUA levels and HUA. We searched the PubMed, Web of Science, and EMBASE databases for relevant articles published up to August 2024 that examined the association between tea drinking, SUA levels, and HUA. The types of tea were categorized as green tea and black tea. A random effects model was used to assess the combined effect sizes of the included studies and their corresponding 95% confidence intervals (CIs). Publication bias was assessed using the Egger test. We included 16 studies involving 285,221 participants that investigated the effect of tea drinking on SUA levels and HUA. Seven papers explored the association between tea drinking and SUA levels. The results showed that the highest and lowest tea consumption categories were associated with elevated SUA levels (WMD = 9.76 μmol/L, 95% CI: 2.03, 17.49, P = 0.013). For the prevalence of HUA, 10 studies were included. There was no significant difference in the overall multivariate corrected ratio (OR) between the highest and lowest tea consumption categories (OR = 1.17, 95% CI: 0.97, 1.42, P = 0.097). The available data suggest that tea drinking may be associated with elevated SUA levels. However, the current evidence does not demonstrate an association between tea drinking and elevated HUA prevalence. Due to the limited number of studies, further well-designed prospective studies and randomized controlled trials are needed to elaborate on these issues.
关于饮茶对血清尿酸（SUA）和高尿酸血症（HUA）的影响，研究结果并不一致。因此，我们进行了一项荟萃分析，以评估饮茶与SUA水平及HUA之间的关联。我们在PubMed、科学网和EMBASE数据库中检索了截至2024年8月发表的相关文章，这些文章研究了饮茶、SUA水平和HUA之间的关联。茶的类型分为绿茶和红茶。采用随机效应模型评估纳入研究的合并效应大小及其相应的95%置信区间（CI）。使用Egger检验评估发表偏倚。我们纳入了16项涉及285221名参与者的研究，这些研究调查了饮茶对SUA水平和HUA的影响。七篇论文探讨了饮茶与SUA水平之间的关联。结果显示，最高和最低饮茶量类别与SUA水平升高相关（加权均数差[WMD]=9.76μmol/L，95%CI：2.03，17.49，P=0.013）。对于HUA的患病率，纳入了10项研究。最高和最低饮茶量类别之间的总体多变量校正比值比（OR）无显著差异（OR=1.17，95%CI：0.97，1.42，P=0.097）。现有数据表明，饮茶可能与SUA水平升高有关。然而，目前的证据并未证明饮茶与HUA患病率升高之间存在关联。由于研究数量有限，需要进一步设计良好的前瞻性研究和随机对照试验来详细阐述这些问题。
