DeRossi R, Jardim P H A, Hermeto L C, Pagliosa R C
Department of Veterinary Medicine-Surgery and Anesthesiology, Faculty of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Aust Vet J. 2015 May;93(5):164-9. doi: 10.1111/avj.12313.
The aim of this study was to evaluate the combination of bupivacaine and methadone administered epidurally in sheep.
Six healthy female mixed-breed sheep weighing 35-46 kg and aged 12-18 months were included. Each sheep was assigned to receive three treatments: 0.5 mg/kg 0.25% bupivacaine (BP), 0.3 mg/kg 1% methadone (MT) or 0.25 mg/kg bupivacaine and 0.15 mg/kg methadone (BPMT). All drugs were injected into the lumbosacral space through an epidural catheter. Each animal received each treatment at random. Heart rate, arterial blood pressure (systolic, diastolic and mean), respiratory rate, rectal temperature, analgesia, sedation and motor block were determined before treatment and at predetermined intervals.
The duration of analgesia was 240, 220, and 180 min for BP, MT and BPMT, respectively (P < 0.05). Motor block for all agents was mild to moderate. None or the treatments significantly altered the heart rate, blood pressure or respiratory rate.
Our findings suggest that lumbosacral epidural administration of bupivacaine, methadone or a combination of the two drugs can provide perioperative analgesia in sheep as part of their management for surgical procedures in the flank and hindlimbs.
本研究旨在评估布比卡因和美沙酮在绵羊硬膜外联合给药的效果。
纳入6只体重35 - 46千克、年龄12 - 18个月的健康雌性杂种绵羊。每只绵羊接受三种治疗：0.5毫克/千克0.25%布比卡因（BP）、0.3毫克/千克1%美沙酮（MT）或0.25毫克/千克布比卡因与0.15毫克/千克美沙酮（BPMT）。所有药物均通过硬膜外导管注入腰骶间隙。每只动物随机接受每种治疗。在治疗前及预定时间间隔测定心率、动脉血压（收缩压、舒张压和平均压）、呼吸频率、直肠温度、镇痛、镇静和运动阻滞情况。
BP、MT和BPMT的镇痛持续时间分别为240、220和180分钟（P < 0.05）。所有药物的运动阻滞均为轻至中度。无一治疗显著改变心率、血压或呼吸频率。
我们的研究结果表明，腰骶部硬膜外给予布比卡因、美沙酮或两种药物联合使用，可作为绵羊侧腹和后肢手术围手术期镇痛管理的一部分。
