Laboratoire Plasticité et Physio-Pathologie de la Motricité, UMR 6196, CNRS, 31 Chemin J. Aiguier, 13402 Marseille Cedex 20, France.
Clin Neurophysiol. 2011 Jan;122(1):153-62. doi: 10.1016/j.clinph.2010.05.022. Epub 2010 Jun 17.
To study the modifications induced by training of a coordinated movement on the primary motor cortex (M1) maps of one proximal muscle and one distal muscle activated alone and during their co-contraction.
Six healthy female sport students performed a 6-week training program during which they were trained in darts 3-4 times a week. At the end each subject had made more than 1200 throws. Transcranial magnetic stimulation (TMS) was used to map the proximal medial deltoid (MD) and the distal brachio-radialis (BR) muscle representations on M1. Motor evoked potentials (MEPs) amplitude and excitability curves were used to test corticomotor excitability.
The cortical representation areas of each muscle separately increased after training. The cortical representation and the excitability curve of the BR muscle increased during co-activation with the MD. Combining co-contraction and training produced a further enlargement of the M1 representation of the BR muscle.
The enlargement of the BR representation in M1 suggests the development of overlapping zones specifying functional synergies between distal and proximal muscles.
Our findings support the idea that training of a coordinated movement involving several muscles and joints requires an activity-dependent coupling of cortical networks.
研究协调运动训练对单独激活和共同收缩时的一个近端肌肉和一个远端肌肉的初级运动皮层（M1）图谱的影响。
六名健康的女性运动学生进行了为期 6 周的训练计划，每周训练 3-4 次投掷。在每个受试者都进行了 1200 多次投掷。使用经颅磁刺激（TMS）来绘制 M1 上近端内侧三角肌（MD）和远端肱桡肌（BR）的肌肉代表区。使用运动诱发电位（MEP）振幅和兴奋性曲线来测试皮质运动兴奋性。
训练后，每个肌肉的皮质代表区都增加了。BR 肌肉的皮质代表区和兴奋性曲线在与 MD 共同激活时增加。将共同收缩和训练相结合，导致 BR 肌肉的 M1 代表区进一步扩大。
M1 中 BR 代表区的扩大表明，在涉及多个肌肉和关节的协调运动训练中，需要皮质网络的活动依赖性耦合。
我们的发现支持了这样一种观点，即涉及多个肌肉和关节的协调运动训练需要皮质网络的活动依赖性耦合。
