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本文引用的文献

1
Case report: cystic fibrosis, lung transplantation, and the novel H1N1 flu.病例报告：囊性纤维化、肺移植与新型甲型H1N1流感
Transplant Proc. 2010 Jul-Aug;42(6):2270-3. doi: 10.1016/j.transproceed.2010.05.028.
2
Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study.实体器官移植受者感染甲型 H1N1 流感的结局：一项多中心队列研究。
Lancet Infect Dis. 2010 Aug;10(8):521-6. doi: 10.1016/S1473-3099(10)70133-X. Epub 2010 Jul 9.
3
Pandemic influenza (H1N1): impact on lung transplant recipients and candidates.大流行性流感（H1N1）：对肺移植受者和候选者的影响。
J Heart Lung Transplant. 2010 Sep;29(9):1034-8. doi: 10.1016/j.healun.2010.05.007. Epub 2010 Jun 16.
4
A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipients.一项前瞻性分子监测研究评估了社区获得性呼吸道病毒在肺移植受者中的临床影响。
Transplantation. 2010 Apr 27;89(8):1028-33. doi: 10.1097/TP.0b013e3181d05a71.
5
Novel swine-origin (S-OIV) H1N1 influenza A pneumonia in a lung transplant patient: a case report and review of the literature on performance characteristics of rapid screening tests for the S-OIV.肺移植患者中新型猪源（S-OIV）H1N1 流感 A 肺炎：一例病例报告及对 S-OIV 快速筛查检测性能特征的文献复习。
Am J Med Sci. 2009 Dec;338(6):506-8. doi: 10.1097/MAJ.0b013e3181c78a64.
6
Guidance on novel influenza A/H1N1 in solid organ transplant recipients.新型甲型 H1N1 流感在实体器官移植受者中的指南。
Am J Transplant. 2010 Jan;10(1):18-25. doi: 10.1111/j.1600-6143.2009.02960.x. Epub 2009 Dec 2.
7
Pathological changes associated with the 2009 H1N1 virus.与2009年甲型H1N1流感病毒相关的病理变化。
N Engl J Med. 2009 Nov 12;361(20):2001-3. doi: 10.1056/NEJMc0907171.
8
Lung pathology in fatal novel human influenza A (H1N1) infection.新型致命性人感染甲型 H1N1 流感的肺部病理学改变。
Am J Respir Crit Care Med. 2010 Jan 1;181(1):72-9. doi: 10.1164/rccm.200909-1420OC. Epub 2009 Oct 29.
9
The novel 2009 H1N1 influenza virus pandemic: unique considerations for programs in cardiothoracic transplantation.新型 2009 H1N1 流感病毒大流行：对心肺移植项目的独特考虑。
J Heart Lung Transplant. 2009 Dec;28(12):1341-7. doi: 10.1016/j.healun.2009.10.001. Epub 2009 Oct 23.
10
Salicylates and pandemic influenza mortality, 1918-1919 pharmacology, pathology, and historic evidence.水杨酸盐与1918 - 1919年大流行性流感死亡率：药理学、病理学及历史证据
Clin Infect Dis. 2009 Nov 1;49(9):1405-10. doi: 10.1086/606060.

一名肺移植患者2009年甲型H1N1流感的诊断挑战及对预防和治疗的长期影响：病例报告

Challenges in the diagnosis of 2009 H1N1 in a lung transplant patient and the long-term implications for prevention and treatment: a case report.

作者信息

Davis C S, Deburghgraeve C R, Yong S, Parada J P, Palladino-Davis A G, Lowery E, Gagermeier J, Fisichella P M

机构信息

Department of Surgery, Loyola University Medical Center, Stritch School of Medicine, Maywood, Illinois 60153, USA.

出版信息

Transplant Proc. 2010 Dec;42(10):4295-9. doi: 10.1016/j.transproceed.2010.09.028.

DOI:10.1016/j.transproceed.2010.09.028
PMID:21168686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3065125/
Abstract

Although respiratory viral infections have been associated with acute rejection and bronchiolitis obliterans syndrome, the long-term impact of the novel pandemic influenza A (2009 H1N1) virus on lung transplant patients has not been defined. We describe the diagnostic challenges and long-term consequences of 2009 H1N1 infection in a lung transplant patient, discuss the potential implications for prevention and treatment, and conclude that even timely antiviral therapy may be insufficient to prevent long-term morbidity.

摘要

尽管呼吸道病毒感染与急性排斥反应和闭塞性细支气管炎综合征有关，但新型甲型H1N1流感大流行病毒对肺移植患者的长期影响尚未明确。我们描述了一名肺移植患者感染2009 H1N1的诊断挑战和长期后果，讨论了预防和治疗的潜在意义，并得出结论，即使及时进行抗病毒治疗也可能不足以预防长期发病。