辅助分子是否与血视网膜屏障处T细胞的激活有关？
Are accessory molecules implicated in activation of T cells at the blood-retinal barrier?
作者信息
Liversidge J, Forrester J V
机构信息
Department of Ophthalmology, University of Aberdeen, UK.
出版信息
Curr Eye Res. 1990;9 Suppl:131-4. doi: 10.3109/02713689008999432.
Co-culture of rat retinal pigment epithelial (RPE) cells or retinal capillary endothelial (EC) cells with T lymphocytes from immunised syngeneic rats indicated that RPE cells but not EC could process retinal S-antigen and induce antigen specific T cell activation. Activation of lymphocytes by EC however was also antigen independent, and may be due to T cell (CD2) endothelial cell (LFA-3) ligand interactions which are functional on EC but not RPE.
将大鼠视网膜色素上皮（RPE）细胞或视网膜毛细血管内皮（EC）细胞与来自免疫的同基因大鼠的T淋巴细胞共培养，结果表明RPE细胞而非EC细胞能够处理视网膜S抗原并诱导抗原特异性T细胞活化。然而，EC对淋巴细胞的激活也是抗原非依赖性的，这可能是由于T细胞（CD2）与内皮细胞（LFA-3）的配体相互作用，这种相互作用在EC细胞上起作用，而在RPE细胞上不起作用。
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