Department of Gynecologic Oncology, Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Yunus Emre Mah., Dereboyu Sok. No: 71/2 Yenimahalle, 06170 Ankara, Turkey.
Arch Gynecol Obstet. 2011 Nov;284(5):1253-8. doi: 10.1007/s00404-010-1804-7. Epub 2010 Dec 18.
The present study aims to document the experience of a single center on the reproductive outcome of a cohort of women who were treated with conservative surgery for borderline ovarian tumors and to specify whether their fertility potential is associated with age, tumor histology and surgery type.
A total of 55 women who had undergone conservative surgery for borderline ovarian tumors between January 1999 and January 2009 were eligible. Recurrence rate, fertility outcome and the number of pregnancies were analyzed retrospectively.
Among the study group, 11 women were not sexually active both at the time of surgery and during the follow-up period. Thus, a total of 44 patients attempted pregnancy after conservative surgery and 52.3% of them (23 out of 44) were able to conceive either spontaneously or by in vitro fertilization. The ability to conceive was shown to be associated with age, tumor histology and type of conservative surgery. As expected, the fertility potential correlated positively with decreasing age (correlation coefficient = 0.705, p = 0.001). Moreover, the existence of non-serous histology and the implementation of unilateral cystectomy were found to be associated with the ability to reach a clinical pregnancy (correlation coefficient = 0.585, p = 0.001 and correlation coefficient = 0.587, p = 0.001, respectively).
The primary treatment of borderline ovarian tumors refers to conservative surgery. Younger age, non-serous histology and unilateral cystectomy appear to be associated with favorable reproductive outcome in women who undergo conservative surgery for borderline malignancy of ovary.
本研究旨在记录单中心对接受保守性手术治疗交界性卵巢肿瘤的患者的生殖结局的经验，并明确其生育潜能是否与年龄、肿瘤组织学和手术类型有关。
1999 年 1 月至 2009 年 1 月期间，共有 55 名接受保守性手术治疗交界性卵巢肿瘤的女性符合条件。回顾性分析复发率、生育结局和妊娠次数。
研究组中有 11 名女性在手术时和随访期间均无性生活。因此，共有 44 名患者在接受保守性手术后尝试怀孕，其中 52.3%（23/44）能够自然或通过体外受精怀孕。受孕能力与年龄、肿瘤组织学和保守性手术类型有关。正如预期的那样，生育潜能与年龄呈正相关（相关系数=0.705，p=0.001）。此外，非浆液性组织学的存在和单侧卵巢囊肿切除术的实施与达到临床妊娠的能力相关（相关系数=0.585，p=0.001 和相关系数=0.587，p=0.001）。
交界性卵巢肿瘤的主要治疗方法是保守性手术。对于接受保守性手术治疗卵巢交界性恶性肿瘤的患者，年轻、非浆液性组织学和单侧卵巢囊肿切除术与良好的生殖结局相关。
