TRP 通道在心血管系统中作用的新观点。
Emerging concepts for the role of TRP channels in the cardiovascular system.
机构信息
Laboratory of Ion Channel Research, Katholieke Universiteit Leuven, Physiology, Campus Gasthuisberg O/N, Herestraat 49, bus 802, Leuven B-3000, Belgium.
出版信息
J Physiol. 2011 Apr 1;589(Pt 7):1527-34. doi: 10.1113/jphysiol.2010.202077. Epub 2010 Dec 20.
Abstract
The transient receptor potential (TRP) family of ion channels is a large family of cation selective ion channels, which are expressed and functional in a variety of tissues. In this review we focus on the most recent results detailing the role of TRP channels in the cardiovascular system. The presented results underscore the role of TRP channels in cardiomyocytes, smooth cells and endothelium, and in disease states such as hypertension, cardiac conduction block and cardiac hypertrophy.
摘要
瞬时受体电位（TRP）家族是一大类阳离子选择性离子通道家族，在多种组织中表达和发挥功能。在这篇综述中，我们重点介绍了最近详细阐述 TRP 通道在心血管系统中作用的研究结果。所呈现的结果强调了 TRP 通道在心肌细胞、平滑肌细胞和内皮细胞中的作用，以及在高血压、心脏传导阻滞和心肌肥厚等疾病状态中的作用。
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