From the Dental Clinic, Division of Graduate Periodontics, and the Institute of Studies in Public Health, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Obstet Gynecol. 2011 Jan;117(1):153-165. doi: 10.1097/AOG.0b013e3181fdebc0.
To systematically review the randomized controlled trials that evaluated the effect of periodontal therapy on preterm birth and low birth weight (LBW).
A systematic search was conducted of the PubMed, Bireme, LILACS, and Cochrane databases.
Only randomized controlled trials on the effect of periodontal therapy on preterm birth and LBW were included. The Consolidated Standards of Reporting Trials statement was used in quality assessment and meta-analysis was carried out using random-effects methods.
TABULATION, INTEGRATION, AND RESULTS: The search resulted in 14 clinical studies. Ten articles met the inclusion criteria for preterm birth and four for LBW. Five meta-analyses on preterm birth were performed according to different criteria: 1) use of probing depth and attachment loss for periodontitis definition, relative risk (RR) 0.58 (95% confidence interval [CI] 0.29-1.12) (four studies); 2) controlling for multiparity, RR 0.92 (95% CI 0.72-1.17) (eight studies); 3) controlling for previous preterm birth, RR 0.88 (95% CI 0.67-1.16) (seven studies); 4) controlling for genitourinary infections, RR 0.75 (95% CI 0.57-1.05) (six studies); and 5) all the previous criteria, RR 0.63 (95% CI 0.32-1.22) (three studies). Three meta-analysis on LBW were conducted according to controlling for multiparity, RR 1.03 (95% CI 0.76-1.40) (four studies); controlling for previous preterm birth, RR 0.93 (95% CI 0.65-1.30) (three studies); and use of probing depth and attachment loss for periodontitis definition, controlling for multiparity, previous preterm birth, and genitourinary infections, RR 0.52 (95% CI 0.10-2.60) (two studies). In all meta-analyses, the effect of periodontal treatment on preterm birth and LBW was not statistically significant.
Results of this meta-analysis do not support the hypothesis that periodontal therapy reduces preterm birth and LBW indices.
系统评价牙周治疗对早产和低出生体重（LBW）的影响的随机对照试验。
对 PubMed、Bireme、LILACS 和 Cochrane 数据库进行了系统检索。
仅纳入牙周治疗对早产和 LBW 影响的随机对照试验。采用 CONSORT 声明进行质量评估，并采用随机效应方法进行荟萃分析。
列表、综合和结果：检索得到 14 项临床研究。10 篇文章符合早产纳入标准，4 篇文章符合 LBW 纳入标准。根据不同标准对早产进行了 5 项荟萃分析：1）使用探诊深度和附着丧失来定义牙周炎，相对风险（RR）0.58（95%置信区间 [CI] 0.29-1.12）（4 项研究）；2）控制多胎，RR 0.92（95% CI 0.72-1.17）（8 项研究）；3）控制早产史，RR 0.88（95% CI 0.67-1.16）（7 项研究）；4）控制生殖道感染，RR 0.75（95% CI 0.57-1.05）（6 项研究）；5）所有上述标准，RR 0.63（95% CI 0.32-1.22）（3 项研究）。根据控制多胎，对 LBW 进行了 3 项荟萃分析，RR 1.03（95% CI 0.76-1.40）（4 项研究）；控制早产史，RR 0.93（95% CI 0.65-1.30）（3 项研究）；以及使用探诊深度和附着丧失来定义牙周炎，控制多胎、早产史和生殖道感染，RR 0.52（95% CI 0.10-2.60）（2 项研究）。在所有荟萃分析中，牙周治疗对早产和 LBW 的影响均无统计学意义。
这项荟萃分析的结果不支持牙周治疗降低早产和 LBW 指数的假设。
