Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Lab Anim (NY). 2011 Jan;40(1):22-6. doi: 10.1038/laban0111-22.
In order for their research to be legitimate, scientists carrying out research using animals must comply with rules and regulations. The 3Rs (replacement, reduction and refinement) are one set of guidelines that help to promote the ethical use of animals for research. An important question is whether implementing the principles of the 3Rs in legal regulations, such as a Directive of the European Parliament and of the Council on the protection of animals used for scientific purposes, will increase compliance with the principles of the 3Rs in research organizations. Previous work suggests that organizational culture is just as important for directing behavior as are formalized rules and regulations. This article introduces the concepts of compliance and organizational culture and discusses their consequences on the implementation of the principles of the 3Rs.
为了使他们的研究合法，使用动物进行研究的科学家必须遵守规则和规定。3R（替代、减少和优化）是一套有助于促进动物在研究中合理使用的准则。一个重要的问题是，在法律法规中实施 3R 原则，例如欧洲议会和理事会关于保护用于科学目的的动物的指令，是否会增加研究机构对 3R 原则的遵守。以前的工作表明，组织文化对于指导行为与正式的规章制度同样重要。本文介绍了合规和组织文化的概念，并讨论了它们对 3R 原则实施的影响。
