Natural Product Drug Discovery Group, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, 23 Westland Row, Dublin 2, Ireland.
J Nat Prod. 2011 Jan 28;74(1):82-5. doi: 10.1021/np100358a. Epub 2010 Dec 21.
Two new furanonaphthoquinones, (3R)-7-methoxy-α-dunnione (5) and (3R)-6-hydroxy-7-methoxy-α-dunnione (6), along with the known (3R)-dunnione (1), (3R)-α-dunnione (2), (3R)-7-hydroxy-α-dunnione (3), and 1-hydroxy-2-methylanthraquinone (4), were isolated from in vitro cultures of Streptocarpus dunnii. The structures of compounds 5 and 6 were established by spectroscopic means. This is the first report of hydroxylated furanonaphthoquinones in a Streptocarpus species. Compounds 1-3 demonstrated cytotoxic activity against a range of breast cancer and pancreatic tumor cell lines.
从 Streptocarpus dunnii 的体外培养物中分离得到了两种新的呋喃并萘醌类化合物：(3R)-7-甲氧基-α-二酮（5）和(3R)-6-羟基-7-甲氧基-α-二酮（6），以及已知的化合物(3R)-二酮（1）、(3R)-α-二酮（2）、(3R)-7-羟基-α-二酮（3）和 1-羟基-2-甲基蒽醌（4）。通过光谱学手段确定了化合物 5 和 6 的结构。这是首次在 Streptocarpus 属中发现羟基化呋喃并萘醌类化合物。化合物 1-3 对多种乳腺癌和胰腺肿瘤细胞系表现出细胞毒性活性。
