厚朴与凹叶厚朴对胃肠动力障碍作用的比较研究
[Comparative study of effect of Magnolia officinalis and M. officinalis var. biloba on gastrointestinal motility dysfunction].
作者信息
Peng Bo, He Rong, Yang Bin, Lu Yanli, Gao Jie, Li Jianrong
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(19):2624-7.
OBJECTIVE
To compare the effect of Magnolia officinalis and M. officinalis var. biloba on gastrointestinal motility dysfunction.
METHOD
The gastrointestinal motility dysfunction induced by atropine and L-Arg were used in this study. The effect of M. officinalis on the gastrointestinal function was evaluated by propulsive motility of the total gastrointestinal tract test by recording the time of excreting carbo medicinalis, the gastric residualrate, the intestinal propulsion rate, the serum levels of D-xylose, motilin (MTL) and gastrin (GAS). ED50 were calculated with Bliss's method.
RESULT
M. officinalis and M. officinalis var. biloba improved the gastrointestinal motility, decreased the gastric residual rate, enhanced the intestinal propulsion rate and increased serum levels of D-xylose, motilin (MTL) and gastrin(GAS). The ED50 value of M. officinalis var. biloba was much higher than that of M. officinalis.
CONCLUSION
The effect of improving gastrointestinal motility of M. officinalis was proved to be superior to that of M. officinalis var. biloba.
目的
比较厚朴与凹叶厚朴对胃肠动力障碍的影响。
方法
本研究采用阿托品和L-精氨酸诱导的胃肠动力障碍。通过记录炭末排出时间、胃残留率、肠推进率、血清D-木糖、胃动素（MTL）和胃泌素（GAS）水平，以全胃肠道推进运动试验评估厚朴对胃肠功能的影响。用Bliss法计算半数有效量（ED50）。
结果
厚朴与凹叶厚朴均能改善胃肠动力，降低胃残留率，提高肠推进率，并增加血清D-木糖、胃动素（MTL）和胃泌素（GAS）水平。凹叶厚朴的ED50值远高于厚朴。
结论
厚朴改善胃肠动力的效果被证明优于凹叶厚朴。
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