Neumann T, Lülsdorf K A, Krings P, Reinsch N, Erbel R
Klinik für Kardiologie, Westdeutsches Herzzentrum Essen, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen.
Herz. 2011 Feb;36(1):18-23. doi: 10.1007/s00059-010-3410-7. Epub 2010 Dec 23.
The introduction of antiretroviral therapy has brought cardiac disease as a comorbidity in HIV-infected patients in particular into focus. The present study analyses the results of coronary angiography in this patient population.
Over a time period of 12 years, 101 coronary angiographies were performed in HIV-infected patients. A retrospective analysis included demographic parameters, cardiac history, cardiovascular risk factors, HIV-specific parameters including antiretroviral therapy and the results of coronary angiographies.
Of the subjects included in the study, 89% were men. The mean age in the analysed population was 50.2 years at the time of coronary angiography. Patients had an elevated rate of cardiovascular risk factors including diabetes mellitus (15.9%), arterial hypertension (65.9%), hyperlipidemia (56.8 %) and smoking (68.2 %). Primary coronary angiography demonstrated coronary disease in 59.1%. Of all patients with coronary artery disease, 70% underwent coronary intervention. Subjects who underwent coronary intervention exhibited hyperlipidemia significantly more often (77.8% vs. 42.3%, p=0.02). Cardiovascular risk factors play a prominent role in the development of premature arteriosclerosis in HIV-infected patients. Furthermore, our data highlight the importance of invasive diagnostics in this patient group.
抗逆转录病毒疗法的引入使心脏病成为HIV感染患者的一种合并症，尤其受到关注。本研究分析了该患者群体的冠状动脉造影结果。
在12年的时间里，对HIV感染患者进行了101次冠状动脉造影。回顾性分析包括人口统计学参数、心脏病史、心血管危险因素、HIV特异性参数（包括抗逆转录病毒疗法）以及冠状动脉造影结果。
纳入研究的对象中，89%为男性。在进行冠状动脉造影时，分析人群的平均年龄为50.2岁。患者的心血管危险因素发生率较高，包括糖尿病（15.9%）、动脉高血压（65.9%）、高脂血症（56.8%）和吸烟（68.2%）。初次冠状动脉造影显示冠心病的比例为59.1%。在所有冠心病患者中，70%接受了冠状动脉介入治疗。接受冠状动脉介入治疗的患者高脂血症的发生率明显更高（77.8%对42.3%，p=0.02）。心血管危险因素在HIV感染患者过早动脉硬化的发展中起重要作用。此外，我们的数据突出了该患者群体中侵入性诊断的重要性。
