时间分辨磁共振血管造影：肺动脉高压肺内循环参数评估。
Time-resolved magnetic resonance angiography: evaluation of intrapulmonary circulation parameters in pulmonary arterial hypertension.
机构信息
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
出版信息
J Magn Reson Imaging. 2011 Jan;33(1):225-31. doi: 10.1002/jmri.22428.
PURPOSE
To determine whether pulmonary arterial and venous transit times measured by time-resolved magnetic resonance angiography (MRA) can be used as a diagnostic tool for pulmonary arterial hypertension (PAH).
MATERIALS AND METHODS
Twelve patients with confirmed PAH and 10 healthy volunteers were scanned with Institutional Review Board (IRB) approval. Time-resolved MRA and 2D phase contrast flow images of the pulmonary vasculature were acquired. Pulmonary arterial and venous transit times (PaTT and PvTT) and pulmonary valve flow (PVF) were obtained. Pulmonary arterial and pulmonary venous blood volumes (PaBV and PvBV) were calculated as the product of flow and transit time.
RESULTS
Patients with PAH showed statistically significant increases in PaTT and PvTT (P < 0.0004, P < 0.05, respectively) compared to controls. PaBV (165.2 ± 92.0 mL) was significantly higher in PAH subjects than controls (97.0 ± 47.1 mL) (P < 0.04), whereas PvBV (127.9 ± 148.9 mL) of PAH subjects had no significant increase from those of healthy controls (142.5 ± 104.1 mL) (P < 0.38).
CONCLUSION
Pulmonary arterial transit times measured using time-resolved MRA can be used as a simple, noninvasive metric for detection of altered hemodynamics in PAH.
目的
确定通过时间分辨磁共振血管造影（MRA）测量的肺动脉和静脉通过时间是否可作为肺动脉高压（PAH）的诊断工具。
材料与方法
在机构审查委员会（IRB）批准下，对 12 名确诊的 PAH 患者和 10 名健康志愿者进行了扫描。采集了时间分辨 MRA 和肺动脉血管的二维相位对比流量图像。获得了肺动脉和静脉通过时间（PaTT 和 PvTT）以及肺动脉瓣流量（PVF）。将流量和通过时间的乘积作为肺动脉和肺静脉血容量（PaBV 和 PvBV）进行计算。
结果
与对照组相比，PAH 患者的 PaTT 和 PvTT 均有统计学显著增加（P<0.0004，P<0.05）。PAH 患者的 PaBV（165.2±92.0 mL）明显高于对照组（97.0±47.1 mL）（P<0.04），而 PAH 患者的 PvBV（127.9±148.9 mL）与健康对照组（142.5±104.1 mL）相比没有明显增加（P<0.38）。
结论
通过时间分辨 MRA 测量的肺动脉通过时间可作为检测 PAH 中血流动力学改变的一种简单、无创的指标。
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