Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Langmuir. 2011 Feb 1;27(3):1175-80. doi: 10.1021/la1042734. Epub 2010 Dec 23.
Multifunctional core-shell capsules that triggered release by ultrasound stimulus were one-step fabricated by the coaxial electrospray method. The TiO(2) shell suppressed the initial burst release of the paclitaxel. Fe(3)O(4) and graphene quantum dots inside the oil core functioned successfully for magnetic targeting and fluorescence imaging, respectively. Paclitaxel was trigger released when the dual layer of titania shell cracked under the ultrasound stimulation, and the releasing profile could be controlled by the length of applied ultrasound time.
采用同轴电喷法一步制备了超声刺激触发释放的多功能核壳胶囊。TiO(2)壳抑制了紫杉醇的初始突释。油核内的 Fe(3)O(4)和石墨烯量子点分别成功地实现了磁靶向和荧光成像功能。当二氧化钛壳层在超声刺激下破裂时，紫杉醇被触发释放，并且通过施加超声时间的长度可以控制释放曲线。
