Plant Sciences Department, Montana State University, Bozeman, MT, USA.
Int J Immunogenet. 2010 Oct;37(5):401-5. doi: 10.1111/j.1744-313X.2010.00941.x. Epub 2010 Jun 21.
Almost no studies have been done with respect to major histocompatibility complex (MHC) polymorphism and sequence diversity in bats, although they account for one in five living mammalian species. We analysed MHC Class II DRB polymorphism and sequence diversity in two Mexican verpertilionid bat species, the widespread continental species Myotis velifer and the narrowly distributed (and endangered) island endemic Myotis vivesi. We find extensive DRB polymorphism in the widespread M. velifer, similar to that commonly reported in other mammals. The geographically restricted M. vivesi by contrast shows only very limited polymorphism. We conclude that M. vivesi has undergone a dramatic loss of MHC polymorphism. The significance of this inference in light of other information on population structure and genetic diversity in this species is discussed.
尽管蝙蝠占所有现存哺乳动物物种的五分之一，但针对其主要组织相容性复合体 (MHC) 多态性和序列多样性的研究几乎没有。我们分析了两种墨西哥蹄蝠科蝙蝠物种的 MHC Ⅱ类 DRB 多态性和序列多样性，它们是分布广泛的大陆物种 Myotis velifer 和分布范围狭窄（濒危）的岛屿特有种 Myotis vivesi。我们发现分布广泛的 M. velifer 中存在广泛的 DRB 多态性，与其他哺乳动物中常见的多态性相似。相比之下，地理上受限的 M. vivesi 仅表现出非常有限的多态性。我们得出结论，M. vivesi 经历了 MHC 多态性的剧烈丧失。在考虑该物种的种群结构和遗传多样性的其他信息的情况下，讨论了这一推断的意义。
