Department of Biochemistry and the Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, 701 Ellicott St, Buffalo, New York 14203, USA.
Genome Biol. 2010;11(12):R126. doi: 10.1186/gb-2010-11-12-r126. Epub 2010 Dec 23.
To facilitate identification and characterization of genomic functional elements, we have developed a chromatin architecture alignment algorithm (ArchAlign). ArchAlign identifies shared chromatin structural patterns from high-resolution chromatin structural datasets derived from next-generation sequencing or tiled microarray approaches for user defined regions of interest. We validated ArchAlign using well characterized functional elements, and used it to explore the chromatin structural architecture at CTCF binding sites in the human genome. ArchAlign is freely available at http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html.
为了促进基因组功能元件的鉴定和描述，我们开发了一种染色质结构比对算法（ArchAlign）。ArchAlign 从基于下一代测序或平铺微阵列方法的用户定义感兴趣区域的高分辨率染色质结构数据集中识别共享的染色质结构模式。我们使用经过良好特征描述的功能元件验证了 ArchAlign，并使用它来探索人类基因组中 CTCF 结合位点的染色质结构架构。ArchAlign 可在 http://www.acsu.buffalo.edu/~mjbuck/ArchAlign.html 免费获取。
