Department of Surgery, Massachusetts General Hospital, 50 Blossom Street, Their 340, Boston, MA 02114, USA.
Dis Model Mech. 2011 Jan;4(1):21-30. doi: 10.1242/dmm.003970.
Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological divergence between vertebrates and insects, the modeling of human intestinal diseases is possible in Drosophila because of the high degree of conservation between Drosophila and mammals with respect to the signaling pathways that control intestinal development, regeneration and disease. Furthermore, the genetic amenability of Drosophila makes it an advantageous model species. The well-studied intestinal stem cell lineage, as well as the tools available for its manipulation in vivo, provide a promising framework that can be used to elucidate many aspects of human intestinal pathology. In this Perspective, we discuss recent advances in the study of Drosophila intestinal infection and pathology, and briefly review the parallels and differences between human and Drosophila intestinal regeneration and disease.
最近关于黑腹果蝇肠道病理学的研究结果表明，该模型非常适合研究衰老、应激和感染过程中肠道干细胞的生理学。尽管脊椎动物和昆虫之间存在生理学差异，但由于控制肠道发育、再生和疾病的信号通路在果蝇和哺乳动物之间具有高度保守性，因此在果蝇中模拟人类肠道疾病是可能的。此外，果蝇的遗传可操作性使其成为一种有利的模式生物。经过充分研究的肠道干细胞谱系以及可用于体内操作的工具，为阐明人类肠道病理学的许多方面提供了一个很有前景的框架。在本观点中，我们讨论了果蝇肠道感染和病理学研究的最新进展，并简要回顾了人类和果蝇肠道再生和疾病之间的相似之处和差异。
