Department of Maxillofacial Surgery, 12 de Octubre University Hospital, Madrid, Spain.
Aesthetic Plast Surg. 2011 Aug;35(4):480-6. doi: 10.1007/s00266-010-9640-5. Epub 2010 Dec 24.
This study evaluated the influence of platelet-rich plasma (PRP) on the histologic characteristics of autologous fat grafts to the upper lip of rabbits.
Nine New Zealand white rabbits were used. Eight of the rabbits underwent fat harvest from the groin fat pads using a modified Coleman technique. One side of the upper lip was infiltrated with autologous fat and the other side with fat and PRP. Four of the infiltrated rabbits were killed 8 weeks after the lip augmentation, and the remaining four infiltrated rabbits plus one control case were killed 12 weeks after the procedure. Coronal sections of both upper lips were analyzed microscopically to evaluate the quality of the fat graft, the inflammatory reaction, the presence of oil cysts, the degree of fibrosis, and the neovascularization.
The infiltration of adipose tissue plus PRP presented less inflammatory reaction (p < 0.05) and fewer oil cysts (p < 0.05) than the infiltration of adipose tissue without PRP.
The infiltration of fat tissue plus PRP generates a lower inflammatory reaction and less formation of oil cysts than the infiltration of isolated fat. Platelet-rich plasma increases the maintenance of the transplanted fat cells.
本研究评估了富血小板血浆（PRP）对上唇自体脂肪移植的组织学特征的影响。
使用 9 只新西兰白兔。8 只兔子采用改良的 Coleman 技术从腹股沟脂肪垫中提取脂肪。一侧上唇注射自体脂肪，另一侧注射脂肪和 PRP。4 只浸润兔在唇部增强 8 周后处死，其余 4 只浸润兔加 1 只对照兔在术后 12 周处死。对上下唇的冠状切片进行显微镜分析，以评估脂肪移植物的质量、炎症反应、油囊肿的存在、纤维化程度和新生血管形成。
与单纯脂肪浸润相比，脂肪组织加 PRP 浸润的炎症反应（p<0.05）和油囊肿形成（p<0.05）较少。
与单纯脂肪浸润相比，脂肪组织加 PRP 浸润可产生较低的炎症反应和较少的油囊肿形成。富血小板血浆可增加移植脂肪细胞的维持。
