Nakamura Shinichiro, Ishihara Masayuki, Takikawa Megumi, Murakami Kaoru, Kishimoto Satoko, Nakamura Shingo, Yanagibayashi Satoshi, Kubo Satoshi, Yamamoto Naoto, Kiyosawa Tomoharu
Department of Plastic and Reconstructive Surgery, National Defense Medical College, Saitama, Japan.
Ann Plast Surg. 2010 Jul;65(1):101-6. doi: 10.1097/SAP.0b013e3181b0273c.
This study evaluated the effects of platelet-rich plasma (PRP) on resorption and adipocyte survival in autologous fat-graft of rats prepared with isogenous PRP. Fat grafts prepared without PRP (control group) became united to the tissue adjacent to the implantation site and were significantly resorbed from 30 days. On the other hand, fat grafts prepared with PRP (PRP group) demonstrated little resorption from 30 to 120 days and appeared pink, had a soft, supple feel, and were easily compressible. Histologic sections of grafts in the control and PRP groups at 10 days exhibited similar consolidation of the grafted tissue, which contained morphologically normal adipocytes with different degrees of granulation and capillary formation. From 20 days normal adipocytes were obviously decreased in the control group, while the PRP group demonstrated increased granulation tissue and capillary formation and good maintenance of normal adipocytes for at least 120 days.
本研究评估了富血小板血浆（PRP）对用同源PRP制备的大鼠自体脂肪移植中吸收和脂肪细胞存活的影响。未用PRP制备的脂肪移植（对照组）与植入部位相邻的组织融合，并从30天起显著吸收。另一方面，用PRP制备的脂肪移植（PRP组）在30至120天几乎没有吸收，呈现粉红色，手感柔软、有弹性，且易于压缩。对照组和PRP组移植10天时的组织学切片显示移植组织的巩固情况相似，其中含有形态正常的脂肪细胞，伴有不同程度的颗粒化和毛细血管形成。从20天起，对照组正常脂肪细胞明显减少，而PRP组显示肉芽组织和毛细血管形成增加，且正常脂肪细胞至少维持良好120天。
