Bhat Kavita P, Greer Susanna F
Division of Cellular and Molecular Biology and Phsyiclogy, Department of Biology, Georgia State University, Atlanta, GA 30302, USA.
Biochim Biophys Acta. 2011 Feb;1809(2):150-5. doi: 10.1016/j.bbagrm.2010.11.006. Epub 2010 Dec 22.
The ubiquitin proteasome system (UPS) regulates perhaps the most intriguing balance in all of biology: how cells control protein function and malfunction in order to regulate, and eventually eliminate, the old and error prone while simultaneously synthesizing and orchestrating the new. In light of the growing notion that ubiquitination and the 26S proteasome are central to a multiplicity of diverse cellular functions, we discuss here the proteolytic and non-proteolytic roles of the UPS in regulating pathways ultimately involved in protein synthesis and activity including roles in epigenetics, transcription, and post-translational modifications. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough!
泛素蛋白酶体系统（UPS）调节着生物学中可能最引人入胜的一种平衡：细胞如何控制蛋白质的功能与功能异常，从而调节并最终清除老化和易出错的蛋白质，同时合成并协调新的蛋白质。鉴于泛素化和26S蛋白酶体在多种不同细胞功能中起核心作用这一观点日益受到关注，我们在此讨论UPS在调节最终涉及蛋白质合成和活性的途径中的蛋白水解和非蛋白水解作用，包括其在表观遗传学、转录和翻译后修饰中的作用。本文是名为“26S蛋白酶体：降解并不总是足够！”的特刊的一部分。
