Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77030, TX, USA.
Int Immunopharmacol. 2011 Mar;11(3):295-309. doi: 10.1016/j.intimp.2010.12.006. Epub 2010 Dec 22.
Although consumption of fruits, vegetables, spices, cereals and pulses has been associated with lower incidence of cancer and other chronic diseases, how these dietary agents and their active ingredients minimize these diseases, is not fully understood. Whether it is oranges, kawa, hops, water-lilly, locorice, wax apple or mulberry, they are all connected by a group of aromatic ketones, called chalcones (1,3-diaryl-2-propen-1-ones). Some of the most significant chalcones identified from these plants include flavokawin, butein, xanthoangelol, 4-hydroxyderricin, cardamonin, 2',4'-dihydroxychalcone, isoliquiritigenin, isosalipurposide, and naringenin chalcone. These chalcones have been linked with immunomodulation, antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, anticancer, and antidiabetic activities. The current review, however, deals with the role of various chalcones in inflammation that controls both the immune system and tumorigenesis. Inflammatory pathways have been shown to mediate the survival, proliferation, invasion, angiogenesis and metastasis of tumors. How these chalcones modulate inflammatory pathways, tumorigenesis and immune system is the focus of this review.
尽管水果、蔬菜、香料、谷物和豆类的消费与较低的癌症和其他慢性疾病发生率有关，但这些饮食因素及其活性成分如何最大限度地减少这些疾病，仍不完全清楚。无论是橙子、卡瓦、啤酒花、睡莲、甘草、莲雾还是桑椹，它们都与一组被称为查耳酮（1,3-二芳基-2-丙烯-1-酮）的芳香酮有关。从这些植物中鉴定出的一些最重要的查耳酮包括 flavokawin、butein、xanthoangelol、4-羟基二氢白藜芦醇、小豆蔻明、2',4'-二羟基查耳酮、异甘草素、异甘草苷和柚皮素查耳酮。这些查耳酮与免疫调节、抗菌、抗真菌、抗病毒、抗炎、抗氧化、抗癌和抗糖尿病活性有关。然而，本综述涉及各种查耳酮在炎症中的作用，炎症既能控制免疫系统，也能促进肿瘤发生。炎症途径已被证明可介导肿瘤的存活、增殖、侵袭、血管生成和转移。这些查耳酮如何调节炎症途径、肿瘤发生和免疫系统是本综述的重点。
