Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA.
J Vasc Interv Radiol. 2011 Feb;22(2):203-11. doi: 10.1016/j.jvir.2010.10.010. Epub 2010 Dec 23.
To evaluate the embolic properties of an alginate-based embolic biomaterial (EmboGel) and its solvent (EmboClear) in treatment of aneurysms.
EmboGel is a mixture of iohexol and alginate that polymerizes into a hydrocoil when delivered through a coaxial catheter with a distal mixing tip, exposing alginate to a calcium chloride solution. In contrast to previously reported embolic agents, EmboGel can be selectively dissolved by EmboClear, a mixture of the enzyme alginate lyase and ethylenediaminetetraacetic acid (EDTA). The embolic and contrast properties of EmboGel were assessed in in vitro models of saccular aneurysm and an aortic aneurysm endoleak. The dissolvability of EmboGel with EmboClear was assessed further after endovascular delivery in the New Zealand white rabbit in the native aortoiliofemoral territory, a created saccular aneurysm, and the native carotid arteries.
EmboGel effectively filled aneurysm cavities in the case of stent excluded saccular and fusiform aneurysms. EmboGel was readily dissolved by EmboClear in vitro and after in vivo embolization. When the distal abdominal aorta and pelvic arteries were occluded with EmboGel, within 1 minute of EmboClear infusion, patency of the aorta and most of the pelvic circulation was regained as noted by angiography. Embolization in the subclavian artery and numerous distal branches was rapidly dissolved by EmboClear. Finally, the carotid artery occluded with EmboGel regained patency after administration of EmboClear.
EmboGel is a dissolvable alginate-based biomaterial that can be used for numerous embolic applications. EmboGel can be selectively dissolved with EmboClear, a solution of alginate lyase and EDTA.
评估藻酸盐基栓塞生物材料（EmboGel）及其溶剂（EmboClear）在治疗动脉瘤中的栓塞特性。
EmboGel 是一种碘海醇和藻酸盐的混合物，通过带有远端混合尖端的同轴导管输送时会聚合成为水凝胶，使藻酸盐暴露于氯化钙溶液中。与之前报道的栓塞剂不同，EmboGel 可以被 EmboClear 选择性溶解，EmboClear 是一种由酶藻酸盐裂解酶和乙二胺四乙酸（EDTA）组成的混合物。在囊状动脉瘤和主动脉瘤内漏的体外模型中评估了 EmboGel 的栓塞和对比特性。进一步评估了 EmboGel 在新西兰白兔的腹主动脉、髂总动脉和股动脉自然区域、人工囊状动脉瘤和颈总动脉的血管内输送后与 EmboClear 一起的溶解情况。
在支架排除的囊状和梭形动脉瘤的情况下，EmboGel 有效地填充了动脉瘤腔。EmboGel 可在体外和体内栓塞后被 EmboClear 轻易溶解。当用 EmboGel 闭塞远端腹主动脉和盆腔动脉时，EmboClear 输注 1 分钟内，造影显示主动脉和大部分盆腔循环的通畅性得到恢复。EmboClear 迅速溶解了锁骨下动脉和许多远端分支的栓塞。最后，用 EmboClear 处理后，颈总动脉的栓塞也恢复了通畅。
EmboGel 是一种可溶解的藻酸盐基生物材料，可用于多种栓塞应用。EmboGel 可以用 EmboClear 选择性溶解，EmboClear 是一种藻酸盐裂解酶和 EDTA 的溶液。
