Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Research (CNIC), Melchor Fernandez Almagro, 3, E-28029, Madrid, Spain.
Nutr Metab Cardiovasc Dis. 2012 Jun;22(6):510-6. doi: 10.1016/j.numecd.2010.09.009. Epub 2010 Dec 24.
In Spain, the incidence of coronary heart disease is below that expected based on the burden of classic cardiovascular risk factors present in the population. Whether the risk associated with metabolic syndrome is lower in Spain deserves to be investigated. This study evaluates the association of incident clinical coronary heart disease with metabolic syndrome and each of its individual defining components in a sample of Spanish working males.
Among the workers of a factory (MESYAS registry), 208 incident cases of coronary heart disease (between 1981 and 2005) were age-matched with 2080 healthy workers visited in 2004-2005. Metabolic syndrome was characterized using modified criteria of the joint consensus definition (2009). Metabolic syndrome was strongly associated with coronary heart disease (OR = 4.03; 95% CI: 2.98, 5.45) and the risk seemed to be fully explained by metabolic syndrome components (OR = 0.84, p = 0.54 after adjustment). Odds ratios for the independent effects of the diagnostic criteria were: hypertriglyceridemia (OR = 3.39, p < 0.001), hyperglycemia (OR = 2.70, p < 0.001), low HDL cholesterol (OR = 2.35, p < 0.001), hypertension (OR = 1.49, p = 0.016) and overweight (OR = 1.07, p = 0.678). Young workers showed a higher risk associated with metabolic syndrome.
The risk associated with metabolic syndrome is fully explained by its components considered independently. The risk of coronary heart disease in a Spanish male working population is considerably increased among those with metabolic syndrome, by a factor similar to that described for other countries. Public health measures to prevent a rise in the prevalence of metabolic syndrome are advisable to minimize cardiovascular disease rate in Spain.
在西班牙，冠心病的发病率低于人群中存在的经典心血管危险因素所预期的水平。代谢综合征相关的风险是否低于西班牙值得研究。本研究评估了代谢综合征及其各组成部分与西班牙男性工人发生临床冠心病的相关性。
在一家工厂的工人（MESYAS 登记处）中，年龄匹配了 208 例冠心病（1981 年至 2005 年之间）的病例，以及 2004 年至 2005 年间检查的 2080 名健康工人。代谢综合征采用联合共识定义（2009 年）的改良标准进行描述。代谢综合征与冠心病密切相关（OR=4.03；95%CI：2.98，5.45），并且风险似乎完全由代谢综合征成分解释（调整后 OR=0.84，p=0.54）。独立诊断标准的比值比为：高甘油三酯血症（OR=3.39，p<0.001）、高血糖症（OR=2.70，p<0.001）、低 HDL 胆固醇（OR=2.35，p<0.001）、高血压（OR=1.49，p=0.016）和超重（OR=1.07，p=0.678）。年轻工人的代谢综合征相关风险更高。
代谢综合征相关风险完全由其独立成分解释。在西班牙男性劳动人口中，代谢综合征与冠心病风险显著增加，风险因素与其他国家相似。为了降低西班牙心血管疾病的发病率，建议采取公共卫生措施来预防代谢综合征的流行率上升。
