Department of Cardiology, Santa Marta Hospital, Centro Hospitalar Lisboa Central, EPE, Lisbon, Portugal.
J Clin Hypertens (Greenwich). 2012 Aug;14(8):507-13. doi: 10.1111/j.1751-7176.2012.00630.x. Epub 2012 Apr 24.
The aim of this investigation was to analyze metabolic syndrome (MS) impact on carotid intima-media thickness (cIMT). Prospective study of 300 patients with suspected coronary artery disease admitted for an elective coronary angiography were evaluated. Patients with previously known cardiac disease were excluded. In the population, 23.0% were diabetics and 40.5% had MS (but no diabetes). cIMT was not significantly different in patients with MS, but was significantly higher in diabetic patients compared with MS and control patients. Independent predictors of cIMT were age, male gender, insulin, and high-density lipoprotein (HDL) cholesterol (the last one with an inverse association). In patients without MS, only age and HDL cholesterol were associated. In patients with MS, independent predictors were age, male gender, and glucose, and abdominal obesity showed an inverse relationship. In patients with stable angina, MS is not an independent predictor of cIMT. Nonmodifiable variables (age and gender) are the most important determinants of cIMT, as well as blood glucose, in MS patients. Abdominal obesity was protective. J Clin Hypertens (Greenwich). 2012;00:00-00. ©2012 Wiley Periodicals, Inc.
本研究旨在分析代谢综合征 (MS) 对颈动脉内膜中层厚度 (cIMT) 的影响。对 300 例疑似冠心病行选择性冠状动脉造影的患者进行了前瞻性研究。排除了有既往心脏疾病的患者。在该人群中，23.0%的患者患有糖尿病，40.5%的患者患有 MS（但无糖尿病）。MS 患者的 cIMT 无显著差异，但与 MS 和对照组患者相比，糖尿病患者的 cIMT 显著更高。cIMT 的独立预测因子为年龄、男性、胰岛素和高密度脂蛋白（HDL）胆固醇（后者呈负相关）。在无 MS 的患者中，仅年龄和 HDL 胆固醇与 cIMT 相关。在 MS 患者中，独立预测因子为年龄、男性和血糖，而腹型肥胖呈负相关。在稳定型心绞痛患者中，MS 不是 cIMT 的独立预测因子。不可变变量（年龄和性别）是 MS 患者 cIMT 的最重要决定因素，血糖和腹型肥胖也是如此。腹型肥胖具有保护作用。J Clin Hypertens (Greenwich). 2012;00:00-00. ©2012 Wiley Periodicals, Inc.
