Smith P C
Am J Vet Res. 1978 Aug;39(8):1369-72.
Intranasal and intraperitoneal exposure of English ferrets (Mustela putorius furo L) to infectious bovine rhinotracheitis virus caused acute and chronic infections of the respiratory tract. The clinical syndrome was characterized by sneezing, coughing, and anorexia from postexposure days (PED) 3 to 7. Mucopurulent exudate was observed in the posterior nares and pharyngeal area of ferrets euthanatized on PED 4 and 8. The virus was readily recovered from the turbinates, respiratory tract epithelium of the pharynx, retropharyngeal lymph nodes, trachea, lungs, and spleen of animals euthanatized on PED 4, but only from the respiratory tract epithelium of the pharynx in ferrets euthanatized on PED 8 and 12. Results of histopathologic studies revealed an acute suppurative pharyngitis in animals euthanatized on PED 4 and 8. Recrudescence of chronic infection could be elicited by daily intraperitoneal injections of 4.0 mg of dexamethasone. However, daily administration of 2.0 mg of dexamethasone intraperitoneally did not cause more severe clinical disease. Results of serologic studies revealed serum antibody profiles comparable with those expected in experimentally exposed cattle.
将英国雪貂（Mustela putorius furo L）经鼻内和腹腔内途径暴露于传染性牛鼻气管炎病毒后，引发了呼吸道的急性和慢性感染。临床综合征的特征为暴露后第3至7天出现打喷嚏、咳嗽和厌食。在暴露后第4天和第8天实施安乐死的雪貂的后鼻孔和咽部区域观察到了黏液脓性渗出物。在暴露后第4天实施安乐死的动物的鼻甲、咽部呼吸道上皮、咽后淋巴结、气管、肺和脾脏中很容易分离到病毒，但在暴露后第8天和第12天实施安乐死的雪貂中，仅在咽部呼吸道上皮中分离到病毒。组织病理学研究结果显示，在暴露后第4天和第8天实施安乐死的动物中出现了急性化脓性咽炎。每日腹腔注射4.0毫克地塞米松可引发慢性感染的复发。然而，每日腹腔注射2.0毫克地塞米松并未导致更严重的临床疾病。血清学研究结果显示，血清抗体谱与实验性暴露牛所预期的谱型相当。
