Lupton H W, Reed D E
Am J Vet Res. 1979 Sep;40(9):1329-31.
Experimental infection of eastern cottontail rabbits (Sylvilagus floridanus) with infectious bovine rhinotracheitis virus caused acute keratoconjunctivitis and a fatal systemic infection. The clinical syndrome was characterized initially by blepharospasm and ocular discharge. The rabbits were markedly depressed on post-exposure day (PED) 5 and were dead or moribund on PED 6. The virus was readily recovered from liver and adrenal gland tissue on PED 6 and from conjunctival swabs on PED 1 to 6. Histopathologic studies revealed a few necrotic foci in the liver and multiple focal to diffuse necrosis of the adrenal glands. Viral isolation and immunofluorescence tests were used to demonstrate a direct association between infectious bovine rhinotracheitis viral antigens and the lesions.
用传染性牛鼻气管炎病毒对东部棉尾兔（佛罗里达棉尾兔）进行实验性感染，引发了急性角结膜炎和致命的全身性感染。临床综合征最初表现为眼睑痉挛和眼部分泌物。兔子在暴露后第5天明显萎靡，在暴露后第6天死亡或濒死。在暴露后第6天，病毒很容易从肝脏和肾上腺组织中分离出来，在暴露后第1至6天从结膜拭子中分离出来。组织病理学研究显示肝脏中有一些坏死灶，肾上腺有多灶性至弥漫性坏死。病毒分离和免疫荧光试验用于证明传染性牛鼻气管炎病毒抗原与病变之间的直接关联。
