秀丽隐杆线虫的星体蛋白 GLD-1 和 ASD-2 通过调控特定的 RNA 靶标来控制发育。
C. elegans star proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development.
机构信息
Department of Biological Sciences, University at Albany, SUNY, Albany, New York 12222, USA.
出版信息
Adv Exp Med Biol. 2010;693:106-22. doi: 10.1007/978-1-4419-7005-3_8.
PMID:21189689
Abstract
A comprehensive understanding of the C. elegans STAR proteins GLD-1 and ASD-2 is emerging from a combination of studies. Those employing genetic analysis reveal in vivo function, others involving biochemical approaches pursue the identification of mRNA targets through which these proteins act. Lastly, mechanistic studies provide the molecular pathway of target mRNA regulation.
摘要
综合运用遗传学分析和生物化学方法的研究，使我们对秀丽隐杆线虫的 STAR 蛋白 GLD-1 和 ASD-2 有了更全面的认识。前者通过遗传分析揭示了这些蛋白的体内功能，后者则通过生化方法鉴定了这些蛋白的作用靶标 mRNA。最后，通过机制研究阐明了靶标 mRNA 调控的分子途径。
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