Health Science Programme, State University of Montes Claros, Montes Claros, Brazil.
Med Oral Patol Oral Cir Bucal. 2011 Sep 1;16(6):e757-62. doi: 10.4317/medoral.16954.
It was evaluated epidemiological aspects of primary lip squamous cell carcinoma (LSCC) and its associations with clinicopathological factors.
This retrospective, cross-sectional study analysed a socio-demographic, clinical, and morphological data of HNSCC in a Brazilian population (n=30). Data analysis included descriptive statistics and bivariate analyses using the chi-square and Fisher 's exact tests to compare the variables.
The LSCC represented 10.8% of all oral cavity squamous cell carcinoma. Lip malignant disease was more prevalent in elderly men, with male-to-female ratio of 5:1. Lower lip was more affected. It was observed high rates of chronic solar exposure, and tobacco and alcohol drinking habits. Clinically, early TNM staging, small tumour lesions, and non-metastatic disease were predominant findings. It was identified a high frequency of well differentiated tumor samples. Worse Karnofsky performance status was associated with cervical metastasis.
Our findings showed that LSCC patients exhibited similar epidemiological and clinical profiles as noted in other studies. Still, the occurrence of metastatic disease was associated with a worse physical performance status of the LSCC patients during diagnosis.
评估原发性唇鳞状细胞癌（LSCC）的流行病学特征及其与临床病理因素的关系。
本回顾性、横断面研究分析了巴西人群（n=30）头颈部鳞状细胞癌的社会人口统计学、临床和形态学数据。数据分析包括描述性统计和使用卡方和 Fisher 精确检验进行的两变量分析，以比较变量。
LSCC 占所有口腔鳞状细胞癌的 10.8%。唇部恶性疾病在老年男性中更为常见，男女比例为 5:1。下唇受影响更大。观察到慢性太阳暴露、吸烟和饮酒习惯的发生率较高。临床上，早期 TNM 分期、肿瘤病变小和非转移性疾病是主要发现。高分化肿瘤样本的频率较高。较差的 Karnofsky 表现状态与颈部转移相关。
我们的研究结果表明，LSCC 患者的流行病学和临床特征与其他研究相似。然而，转移性疾病的发生与 LSCC 患者在诊断时身体表现状态较差有关。
