儿童和青少年肥胖的药物治疗：现状与未来
Pharmacological treatment of obesity in children and adolescents: present and future.
作者信息
Iughetti Lorenzo, China Mariachiara, Berri Rossella, Predieri Barbara
机构信息
Obesity Research Center, Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy.
出版信息
J Obes. 2011;2011:928165. doi: 10.1155/2011/928165. Epub 2010 Dec 15.
Abstract
The prevalence of overweight and obesity is increasing in children and adolescents worldwide raising the question on the approach to this condition because of the potential morbidity, mortality, and economic tolls. Dietetic and behavioral treatments alone have only limited success; consequently, discussion on strategies for treating childhood and adolescent obesity has been promoted. Considering that our knowledge on the physiological systems regulating food intake and body weight is considerably increased, many studies have underlined the scientific and clinical relevance of potential treatments based on management of peripheral or central neuropeptides signals by drugs. In this paper, we analyze the data on the currently approved obesity pharmacological treatment suggesting the new potential drugs.
摘要
全球儿童和青少年超重及肥胖的患病率正在上升，鉴于其潜在的发病率、死亡率和经济损失，引发了对这种情况应对方法的质疑。仅靠饮食和行为治疗的成功率有限；因此，关于治疗儿童和青少年肥胖症策略的讨论日益增多。鉴于我们对调节食物摄入和体重的生理系统的认识有了显著提高，许多研究强调了基于药物管理外周或中枢神经肽信号的潜在治疗方法的科学和临床相关性。在本文中，我们分析了目前已获批的肥胖症药物治疗的数据，并提出了新的潜在药物。
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