Department of Paediatrics, University of Modena & Reggio Emilia, Modena, Italy.
Ital J Pediatr. 2011 Aug 16;37:38. doi: 10.1186/1824-7288-37-38.
An epidemic of pediatric obesity has occurred across the world in recent years. There are subgroups within the population at high-risk of becoming obese and especially of having experience of precocious cardiovascular and metabolic co-morbidities of obesity. One of these subgroups comprises patients treated for childhood cancers and namely survivors of craniopharyngioma. The high incidence of obesity in this group makes these patients an important disease model to better understand the metabolic disturbances and the mechanisms of weight gain among cancer survivors. The hypothalamic-pituitary axis damage secondary to cancer therapies or to primary tumor location affect long-term outcomes. Nevertheless, the aetiology of obesity in craniopharyngioma is not yet fully understood. The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population.
近年来，全球范围内出现了儿童肥胖症的流行。在肥胖风险较高的人群中存在亚组，特别是那些经历过肥胖相关心血管和代谢合并症的亚组。其中一个亚组包括接受儿童癌症治疗的患者，特别是颅咽管瘤的幸存者。该人群中肥胖症的高发病率使得这些患者成为一个重要的疾病模型，可以更好地了解癌症幸存者的代谢紊乱和体重增加的机制。癌症治疗或原发性肿瘤位置引起的下丘脑-垂体轴损伤会影响长期预后。然而，颅咽管瘤肥胖的病因尚不完全清楚。本综述旨在总结已发表的数据，并研究与该特定人群体重增加相关的最被接受的机制和主要易感因素。
