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人类伏隔核的解剖结构:一项联合形态计量学研究。

Anatomy of the human nucleus accumbens: a combined morphometric study.

作者信息

Mavridis Ioannis, Boviatsis Efstathios, Anagnostopoulou Sophia

机构信息

Department of Anatomy, University of Athens School of Medicine, Mikras Assias str. 75, Goudi, 11527, Athens, Greece.

出版信息

Surg Radiol Anat. 2011 Jul;33(5):405-14. doi: 10.1007/s00276-010-0766-6. Epub 2011 Jan 4.

DOI:10.1007/s00276-010-0766-6
PMID:21203764
Abstract

PURPOSE

The human nucleus accumbens (NA), which belongs to the basal ganglia of the brain, is the main part of the ventral striatum. The purpose of our clinically oriented anatomical-radiologic study was to provide anatomical and imaging data of the human NA, primarily useful to neurosurgeons.

METHODS

For our imaging study, we used cerebral magnetic resonance images (MRIs) from 26 neurosurgical patients (52 NAs). The material for our anatomic study consisted of 32 cerebral hemispheres (32 NAs) from 18 normal human brains which we have in our department (Department of Anatomy) from cadaver donors. We measured and analyzed the dimensions of the NA at specific clinically important transverse, coronal and sagittal levels.

RESULTS

The human NA suffers from age-related but no side- or sex-related morphometric changes. In surgically important stereotactic levels this nucleus is easily identifiable on MRIs.

CONCLUSIONS

We present an anatomic guide of the NA from carefully measured data of our extensive and combined study and we hope that our work will be really helpful to neuroscientists interested in the NA.

摘要

目的

伏隔核(NA)属于脑基底神经节,是腹侧纹状体的主要部分。我们这项以临床为导向的解剖学 - 放射学研究的目的是提供人类NA的解剖学和影像学数据,主要供神经外科医生使用。

方法

在影像学研究中,我们使用了26例神经外科患者(52个NA)的脑磁共振成像(MRI)。解剖学研究材料包括我们解剖学系从尸体捐赠者处获得的18个正常人类大脑的32个脑半球(32个NA)。我们在特定的具有临床重要意义的横断、冠状和矢状层面测量并分析了NA的尺寸。

结果

人类NA存在与年龄相关的形态学变化,但不存在与左右侧或性别相关的形态学变化。在具有手术重要性的立体定向层面上,该核在MRI上易于识别。

结论

我们根据广泛综合研究的精确测量数据,展示了NA的解剖学指南,希望我们的工作能真正帮助对NA感兴趣的神经科学家。

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Transient Manic-like Episode Following Bilateral Deep Brain Stimulation of the Nucleus Accumbens and the Internal Capsule in a Patient With Tourette Syndrome.抽动秽语综合征患者双侧伏隔核和内囊深部脑刺激后出现短暂躁狂样发作。
Neuromodulation. 2008 Apr;11(2):128-31. doi: 10.1111/j.1525-1403.2008.00154.x.
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The human nucleus accumbens: where is it? A stereotactic, anatomical and magnetic resonance imaging study.人类伏隔核:它在哪里?一项立体定向、解剖学和磁共振成像研究。
Neuromodulation. 2008 Jan;11(1):13-22. doi: 10.1111/j.1525-1403.2007.00138.x.
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Preliminary findings in ablating the nucleus accumbens using stereotactic surgery for alleviating psychological dependence on alcohol.
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Modeling nucleus accumbens : A Computational Model from Single Cell to Circuit Level.伏隔核建模:从单细胞到电路水平的计算模型
J Comput Neurosci. 2021 Feb;49(1):21-35. doi: 10.1007/s10827-020-00769-y. Epub 2020 Nov 9.
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How Deep Brain Stimulation of the Nucleus Accumbens Affects the Cingulate Gyrus and Vice Versa.伏隔核的深部脑刺激如何影响扣带回,反之亦然。
Brain Sci. 2019 Jan 4;9(1):5. doi: 10.3390/brainsci9010005.
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The intranuclear length of the electrode trajectory according to the 'port' model for deep brain stimulation of the nucleus accumbens.根据用于伏隔核深部脑刺激的“端口”模型,电极轨迹的核内长度。
Ann Transl Med. 2018 Feb;6(3):67. doi: 10.21037/atm.2017.11.09.
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Connectivity-based parcellation of the nucleus accumbens into core and shell portions for stereotactic target localization and alterations in each NAc subdivision in mTLE patients.基于连接的伏隔核核心和壳部分的分割,用于立体定向靶点定位,以及在 mTLE 患者的每个 NAc 细分部分中的变化。
Hum Brain Mapp. 2018 Mar;39(3):1232-1245. doi: 10.1002/hbm.23912. Epub 2017 Dec 20.
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Ann Transl Med. 2017 Oct;5(20):402. doi: 10.21037/atm.2017.07.13.
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Brain Behav. 2017 Jul 14;7(8):e00769. doi: 10.1002/brb3.769. eCollection 2017 Aug.
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立体定向手术损毁伏隔核治疗酒精依赖的初步研究
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Deep-brain stimulation of the nucleus accumbens in obsessive compulsive disorder: clinical, surgical and electrophysiological considerations in two consecutive patients.在强迫症中对伏隔核进行深部脑刺激:两位连续患者的临床、手术和电生理考虑因素。
Neurol Sci. 2010 Jun;31(3):353-9. doi: 10.1007/s10072-009-0214-8. Epub 2010 Feb 3.
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Smoking cessation and weight loss after chronic deep brain stimulation of the nucleus accumbens: therapeutic and research implications: case report.慢性伏隔核深部脑刺激后戒烟和体重减轻:治疗和研究意义:病例报告。
Neurosurgery. 2010 Jan;66(1):E218; discussion E218. doi: 10.1227/01.NEU.0000360570.40339.64.
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Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: Outcomes after one year.对难治性强迫症患者进行伏隔核单侧深部脑刺激:一年后的结果
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Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression.伏隔核深部脑刺激可降低治疗抵抗性抑郁症的抑郁和焦虑评分。
Biol Psychiatry. 2010 Jan 15;67(2):110-6. doi: 10.1016/j.biopsych.2009.09.013.
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The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia.海马体和伏隔核作为精神分裂症神经外科干预的潜在治疗靶点。
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Deep brain stimulation in the nucleus accumbens for intractable Tourette's syndrome: follow-up report of 36 months.伏隔核深部脑刺激治疗难治性抽动秽语综合征:36个月随访报告
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