Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China.
Protein Cell. 2010 Jun;1(6):520-36. doi: 10.1007/s13238-010-0065-3. Epub 2010 Jul 7.
As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years. This is largely due to the advent of newer generations of sequencing platforms, offering ever-faster and cheaper ways to analyze sequences. In our previous review, we looked into technical characteristics of the next-generation sequencers and provided prospective insights into their future development. In this article, we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications.
作为生物医学研究的关键技术之一，DNA 测序不仅提高了其生产力，而且在过去几年中也被应用到了新的领域。这在很大程度上要归功于新一代测序平台的出现，它们提供了更快、更便宜的分析序列的方法。在我们之前的综述中，我们研究了下一代测序仪的技术特点，并对它们的未来发展进行了前瞻性的分析。在本文中，我们简要概述了目前市场上主要的商业化平台的优缺点，并重点介绍了它们在广泛应用中的适用性。
