Department of Nutritional Sciences, Chandlee Laboratory, The Pennsylvania State University, University Park, PA, USA.
Eur J Clin Nutr. 2011 Mar;65(3):415-8. doi: 10.1038/ejcn.2010.273. Epub 2011 Jan 5.
Fasting leptin and ghrelin levels were measured in 36 insulin-sensitive (IS) and 28 insulin-resistant (IR) men who consumed a legume-enriched low-glycemic index (LG) diet or healthy American (HA) diet in a randomly ordered cross-over feeding study consisting of two 4-week periods. Weight remained stable over the entire study. Fasting plasma leptin was significantly reduced from pre-study levels by both the LG (18.8%, P < 0.001) and HA (16.1%, P < 0.001) diets, whereas fasting ghrelin did not change. By subgroup analysis according to prestudy insulin status, leptin was reduced in IR subjects after both the LG (17.1%, P < 0.01) and the HA (33.3%, P < 0.001) diets, whereas IS subjects responded only after the LG diet (23.1%, P < 0.01). Thus, a legume-rich LG index diet may be a beneficial strategy for reducing circulating leptin concentrations, even under conditions of weight maintenance.
在一项随机交叉喂养研究中，36 名胰岛素敏感（IS）男性和 28 名胰岛素抵抗（IR）男性分别食用富含豆类的低血糖指数（LG）饮食或健康美国（HA）饮食，测量了他们的禁食瘦素和胃饥饿素水平。整个研究期间体重保持稳定。两种饮食都使空腹血浆瘦素水平显著降低（LG 组降低 18.8%，P < 0.001；HA 组降低 16.1%，P < 0.001），而空腹胃饥饿素没有变化。根据胰岛素状态的预研究亚组分析，LG 组（17.1%，P < 0.01）和 HA 组（33.3%，P < 0.001）都使 IR 受试者的瘦素降低，而 IS 受试者仅在 LG 组饮食后才有反应（23.1%，P < 0.01）。因此，富含豆类的 LG 指数饮食可能是降低循环瘦素浓度的有益策略，即使在维持体重的情况下也是如此。
