Physiology and Experimental Medicine Research Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada.
Immunology. 2011 Mar;132(3):307-14. doi: 10.1111/j.1365-2567.2010.03396.x. Epub 2011 Jan 5.
Dendritic cells (DCs) play a pivotal role in regulating the balance between immunity and tolerance of the immune system. Recent advancements in DC biology and techniques for manipulating the function of these cells have shown their immense therapeutic potential for treating a variety of immune disorders. Theoretically, antigen-specific tolerogenic DCs can be generated in vitro and delivered to patients to correct the dysfunctional immune responses that attack their own tissues or over-react to innocuous foreign antigens. However, DCs are a heterogeneous population of cells with differences in cell surface makers, differentiation pathways and functions. Studies are needed to examine which subset of DCs can be used for what type of applications. Furthermore, most of the information on tolerogenic DCs has been obtained from animal models and translational studies are needed to examine how a DC therapeutic strategy can be implemented clinically to modulate immunity.
树突状细胞 (DCs) 在调节免疫系统的免疫和耐受平衡方面发挥着关键作用。最近在 DC 生物学和操纵这些细胞功能的技术方面的进展表明，它们在治疗各种免疫紊乱方面具有巨大的治疗潜力。从理论上讲，可以在体外生成抗原特异性耐受性 DC，并将其递送给患者，以纠正攻击自身组织或对无害外来抗原过度反应的功能失调的免疫反应。然而，DC 是一群具有不同细胞表面标志物、分化途径和功能的异质性细胞。需要进行研究以确定哪种 DC 亚群可用于哪种类型的应用。此外，关于耐受性 DC 的大部分信息都是从动物模型中获得的，需要进行转化研究，以研究如何在临床上实施 DC 治疗策略来调节免疫。
