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筛查连接大脑皮层的基因。

Screening for genes that wire the cerebral cortex.

机构信息

Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, 46 rue d'Ulm, 75230 Paris cedex 05, France.

出版信息

BMC Biol. 2011 Jan 7;9:1. doi: 10.1186/1741-7007-9-1.

DOI:10.1186/1741-7007-9-1
PMID:21214944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3017517/
Abstract

Thalamocortical projections convey visual, somatosensory and auditory information to the cerebral cortex. A recent report in Neural Development shows how a forward genetic screen has enabled the identification of novel mutations affecting specific decision points of thalamocortical axon pathfinding.

摘要

丘脑皮质投射将视觉、躯体感觉和听觉信息传递到大脑皮层。《神经发育》的一篇最新报道显示，正向遗传学筛选如何使人们能够识别出影响特定丘脑皮质轴突寻路决策点的新型突变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/867c/3017517/0638cd146818/1741-7007-9-1-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/867c/3017517/0638cd146818/1741-7007-9-1-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/867c/3017517/0638cd146818/1741-7007-9-1-1.jpg

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A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.利用丘脑皮质轴突报告基因小鼠进行正向遗传学筛选，得到新型神经发育突变体和明显的 Emx2 突变体表型。
Neural Dev. 2011 Jan 7;6:3. doi: 10.1186/1749-8104-6-3.
2
Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon.缝隙蛋白是下丘脑内源性的化学排斥分子，可引导丘脑皮质轴突进入腹侧端脑。
Cereb Cortex. 2009 Jul;19 Suppl 1(Suppl 1):i144-51. doi: 10.1093/cercor/bhp035. Epub 2009 May 11.
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Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice.
自闭症谱系障碍中感觉知觉异常的预测模型。
Int J Mol Sci. 2023 Jan 25;24(3):2367. doi: 10.3390/ijms24032367.
4
Clonality, inbreeding, and hybridization in two extremotolerant black yeasts.两种极端耐受力黑酵母的克隆性、近亲繁殖和杂交。
Gigascience. 2022 Oct 6;11. doi: 10.1093/gigascience/giac095.
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Sensing risk, fearing uncertainty: systems science approach to change.感知风险，畏惧不确定性：变革的系统科学方法。
Front Comput Neurosci. 2014 Mar 31;8:30. doi: 10.3389/fncom.2014.00030. eCollection 2014.
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The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidance.组合基因表达在早期哺乳动物丘脑模式形成和丘脑皮质轴突导向中的重要性。
Front Neurosci. 2012 Mar 15;6:37. doi: 10.3389/fnins.2012.00037. eCollection 2012.
早期前脑布线：利用条件性Celsr3突变小鼠进行基因剖析。
Science. 2008 May 16;320(5878):946-9. doi: 10.1126/science.1155244.
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Comprehensive EMX2 genotyping of a large schizencephaly case series.对大量脑裂畸形病例系列进行全面的EMX2基因分型。
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