Krishna Lalit Kumar Radha, Poulose Jissy Vijo, Goh Cynthia
Department of Palliative Medicine, National Cancer Centre, Singapore.
Indian J Palliat Care. 2010 Sep;16(3):168-73. doi: 10.4103/0973-1075.73668.
The objective of this study has been to examine the frequency of use of artificial hydration in terminally ill cancer patients during the last 48 h of life and the occurrence of symptoms specific to hydration status. Other objectives were to find out if artificial hydration has any impact on survival or had any influence on the patterns of use of opioids and sedatives while under palliative care.
Retrospective review of case notes of palliative care patients who died in a 95 bedded oncology ward was done. Information on demographic profile, duration of palliative care, medication use and on symptoms related to hydration status was collected. Patients on artificial hydration were compared to those who were not on artificial hydration for the above parameters. Survival curves were plotted for both groups using Kaplan-Meier method.
There were 238 patients of which 55.5% were females. The median age was 62 years and the median duration of palliative care was five days. Artificial hydration was given to 59.2% of patients. There was no significant difference in the incidence of symptoms related to hydration status or in the patterns of medication use between patients who received artificial hydration and those who did not. Kaplan-Meier survival curves did not show any significant survival difference (P value=0.9) between the two groups.
Artificial hydration during the last 48 h of life did not have any significant impact on symptoms related to hydration status, medication use or on survival in terminally ill cancer patients under palliative care.
本研究的目的是调查晚期癌症患者在生命的最后48小时内人工补液的使用频率以及与补液状态相关的特定症状的发生情况。其他目的是了解人工补液对生存是否有任何影响,或者在姑息治疗期间对阿片类药物和镇静剂的使用模式是否有任何影响。
对在一个拥有95张床位的肿瘤病房死亡的姑息治疗患者的病历进行回顾性研究。收集了有关人口统计学资料、姑息治疗持续时间、药物使用以及与补液状态相关症状的信息。将接受人工补液的患者与未接受人工补液的患者在上述参数方面进行比较。使用Kaplan-Meier方法为两组绘制生存曲线。
共有238名患者,其中55.5%为女性。中位年龄为62岁,姑息治疗的中位持续时间为5天。59.2%的患者接受了人工补液。接受人工补液的患者与未接受人工补液的患者在与补液状态相关的症状发生率或药物使用模式方面没有显著差异。Kaplan-Meier生存曲线显示两组之间没有显著的生存差异(P值 = 0.9)。
在生命的最后48小时内进行人工补液对姑息治疗下的晚期癌症患者与补液状态相关的症状、药物使用或生存没有任何显著影响。