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由c-jun和激活的c-Ha-ras癌基因诱导的F9胚胎癌细胞分化

Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.

作者信息

Yamaguchi-Iwai Y, Satake M, Murakami Y, Sakai M, Muramatsu M, Ito Y

机构信息

Department of Viral Oncology, Kyoto University, Japan.

出版信息

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8670-4. doi: 10.1073/pnas.87.21.8670.

DOI:10.1073/pnas.87.21.8670
PMID:2122465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC55019/
Abstract

The activated c-Ha-ras oncogene induced AP1-site DNA-binding activity in F9 cells. This induction appeared to be due, at least in part, to the induction of c-jun transcription. Both activated c-Ha-ras and c-jun induced the differentiation of F9 cells to endoderm-like cells. Thus, AP1 appears to play a key role in the initial stage of F9 cell differentiation.

摘要

活化的c-Ha-ras癌基因在F9细胞中诱导了AP1位点的DNA结合活性。这种诱导作用似乎至少部分归因于c-jun转录的诱导。活化的c-Ha-ras和c-jun均诱导F9细胞分化为内胚层样细胞。因此，AP1似乎在F9细胞分化的初始阶段起着关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/4fc31d2997f8/pnas01046-0496-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/988634102d32/pnas01046-0494-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/82bffb79dac5/pnas01046-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/f2d23c5fc7a6/pnas01046-0495-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/884228acf8cd/pnas01046-0496-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/fe7666e0abe7/pnas01046-0496-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/2c064803cad8/pnas01046-0496-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/4fc31d2997f8/pnas01046-0496-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/988634102d32/pnas01046-0494-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/82bffb79dac5/pnas01046-0495-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/f2d23c5fc7a6/pnas01046-0495-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/884228acf8cd/pnas01046-0496-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/fe7666e0abe7/pnas01046-0496-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/2c064803cad8/pnas01046-0496-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1290/55019/4fc31d2997f8/pnas01046-0496-d.jpg

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Differentiation of F9 embryonal carcinoma cells induced by the c-jun and activated c-Ha-ras oncogenes.由c-jun和激活的c-Ha-ras癌基因诱导的F9胚胎癌细胞分化
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JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.

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T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
JDP2是AP-1的一种阻遏物，它募集一种组蛋白去乙酰化酶3复合物以抑制视黄酸诱导的F9细胞分化。
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Teratocarcinomas and mammalian embryogenesis.畸胎癌与哺乳动物胚胎发育
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