Kawamoto Seiji, Kaneoke Mitsuoki, Ohkouchi Kayo, Amano Yuichi, Takaoka Yuki, Kume Kazunori, Aki Tsunehiro, Yamashita Susumu, Watanabe Ken-ichi, Kadowaki Motoni, Hirata Dai, Ono Kazuhisa
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8530, Japan.
Biosci Biotechnol Biochem. 2011;75(1):140-4. doi: 10.1271/bbb.100541. Epub 2011 Jan 7.
We tested the effect of oral administration of fermented sake lees with lactic acid bacteria (FESLAB) on a murine model of allergic rhinitis upon immunization and nasal sensitization with ovalbumin (OVA). We used Lactobacillus paracasei NPSRIk-4 (isolated from sake lees), and L. brevis NPSRIv-8 (from fermented milk) as starter strains to produce the FESLAB. Oral FESLAB administration resulted in the development of significantly fewer sneezing symptoms than those seen in sham control animals given sterile water. We also found that FESLAB suppressed the allergen-induced degranulation of RBL2H3 rat basophilic leukemia cells.
我们测试了口服含乳酸菌的发酵清酒糟（FESLAB）对卵清蛋白（OVA）免疫和鼻致敏的变应性鼻炎小鼠模型的影响。我们使用副干酪乳杆菌NPSRIk - 4（从清酒糟中分离）和短乳杆菌NPSRIv - 8（从发酵乳中分离）作为起始菌株来生产FESLAB。口服FESLAB导致出现打喷嚏症状的小鼠数量显著少于给予无菌水的假对照动物。我们还发现FESLAB抑制了变应原诱导的RBL2H3大鼠嗜碱性白血病细胞脱颗粒。
