Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA.
Clin Interv Aging. 2010 Nov 15;5:323-31. doi: 10.2147/CIA.S9088.
Less than half of older adults with depression achieve remission with antidepressant medications, and rates of remission are even poorer for those with comorbid conditions. Psychosocial interventions have been effective in treating geriatric depression, either alone or better yet, in combination with antidepressant medications. Traditional strategies for nonpharmacological treatment of late-life depression do not specifically address the co-occurring cognitive impairment and disability that is prevalent in this population. Newer therapies are recognizing the need to simultaneously direct treatment efforts in late-life depression towards the triad of depressive symptoms, cognitive dysfunction, and functional disability that is so often found in geriatric depression, and this comprehensive approach holds promise for improved treatment outcomes.
不到一半的老年抑郁症患者通过抗抑郁药物达到缓解，而合并症患者的缓解率甚至更低。心理社会干预措施在治疗老年抑郁症方面非常有效，无论是单独使用还是与抗抑郁药物联合使用。针对老年抑郁症的非药物治疗传统策略并没有专门针对该人群中普遍存在的认知障碍和残疾问题。较新的治疗方法认识到需要将老年抑郁症的治疗重点同时放在抑郁症状、认知功能障碍和功能障碍这三联征上，这在老年抑郁症中经常同时出现，这种全面的方法有望改善治疗结果。
