Cecilia M. Giachelli and Stephen M. Schwartz are at the Department of Pathology SJ-60, University of Washington School of Medicine, Seattle, WA 98195, USA.
Trends Cardiovasc Med. 1995 May-Jun;5(3):88-95. doi: 10.1016/1050-1738(95)00005-T.
Molecular biology has greatly enhanced our ability to identify molecules expressed as a part of the vascular response to injury. Among these, osteopontin is of particular interest. Osteopontin is a multifunctional adhesive glycoprotein implicated in the pathogenesis of a growing number of cardiovascular lesions, including restenosis, atherosclerosis, aortic valve calcification, and repair of myocardial wounds. In this review, we focus on structural, functional, and regulatory properties of osteopontin, which might be particularly relevant to cardiovascular lesion development.
分子生物学极大地增强了我们识别作为血管损伤反应一部分表达的分子的能力。在这些分子中，骨桥蛋白尤为引人注目。骨桥蛋白是一种多功能黏附糖蛋白，与越来越多种心血管病变的发病机制有关，包括再狭窄、动脉粥样硬化、主动脉瓣钙化和心肌损伤的修复。在这篇综述中，我们重点关注骨桥蛋白的结构、功能和调节特性，这些特性可能与心血管病变的发展特别相关。
