Advanced Medical Solutions, Winsford, Cheshire, United Kingdom.
Wound Repair Regen. 2011 Jan-Feb;19(1):1-9. doi: 10.1111/j.1524-475X.2010.00651.x.
The application of antimicrobials in the management of wounds is a complex procedure requiring appropriate clinical decision making, judgment and a thorough understanding of antimicrobial therapies, together with their potential disadvantages. There is considerable direct and indirect evidence for the presence of bacterial biofilms in the chronic wound bed, and it has been demonstrated that bacteria within these biofilms may exhibit both specific and nonspecific antimicrobial tolerance. The antimicrobial tolerance of biofilms is a major concern in the treatment of both infected and nonhealing chronic wounds and an understanding of the mechanisms involved is of fundamental importance in managing wound infections and developing future wound management strategies. The aim of this review is therefore to provide an overview of our current understanding of the mechanisms by which bacteria in wound biofilms can resist conventional antibiotic and antibacterial therapies which is very important to wound healing.
抗菌药物在伤口管理中的应用是一个复杂的过程，需要进行适当的临床决策、判断，并对抗菌治疗及其潜在缺点有透彻的了解。慢性伤口床中存在细菌生物膜的直接和间接证据很多，已经证明这些生物膜内的细菌可能表现出特定和非特定的抗菌耐药性。生物膜的抗菌耐药性是治疗感染和非愈合性慢性伤口的一个主要关注点，了解相关机制对于管理伤口感染和制定未来的伤口管理策略至关重要。因此，本篇综述的目的是概述我们目前对伤口生物膜中细菌如何抵抗常规抗生素和抗菌治疗的机制的理解，这对伤口愈合非常重要。
