Institute of Haematology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Med J Aust. 2011 Jan 17;194(2):65-7. doi: 10.5694/j.1326-5377.2011.tb04169.x.
To determine the impact that mandatory fortification with folic acid of wheat flour used in breadmaking has had on the blood folate levels of an Australian population since it was introduced in September 2009.
DESIGN, SETTING AND PATIENTS: A retrospective analysis of serum and red blood cell (RBC) folate levels of 20,592 blood samples collected between April 2007 and April 2010 from a wide variety of inpatients and outpatients and analysed in a large public hospital diagnostic pathology laboratory.
Prevalences of low levels of serum and RBC folate and monthly mean levels before and after introduction of mandatory fortification.
Between April 2009 and April 2010, there was a 77% reduction in the prevalence of low serum folate levels (from 9.3% to 2.1%) in all samples tested and an 85% reduction in the prevalence of low RBC folate levels (from 3.4% to 0.5%). In April 2010, the prevalence of low RBC folate levels for females of childbearing age was 0.16% for all samples. There was a 31% increase in mean serum folate level (from 17.7 nmol/L to 23.1 nmol/L; t = 9.3, P < 0.01), and a 22% increase in mean RBC folate level (from 881 nmol/L to 1071 nmol/L). The greatest increment in mean serum folate levels occurred in September 2009, the month that mandatory fortification was introduced, although there was evidence of a gradual change during the preceding months.
The introduction of mandatory fortification with folic acid has significantly reduced the prevalence of folate deficiency in Australia, including in women of childbearing age.
自 2009 年 9 月强制在面包用小麦粉中添加叶酸以来，确定其对澳大利亚人群血液叶酸水平的影响。
设计、设置和患者：对 2007 年 4 月至 2010 年 4 月期间在一家大型公立医院诊断病理学实验室分析的 20592 份来自各种住院和门诊患者的血清和红细胞（RBC）叶酸水平的回顾性分析。
血清和 RBC 叶酸水平低的患病率以及强制添加叶酸前后的月平均水平。
在所有检测样本中，2009 年 4 月至 2010 年 4 月期间，低血清叶酸水平的患病率降低了 77%（从 9.3%降至 2.1%），低 RBC 叶酸水平的患病率降低了 85%（从 3.4%降至 0.5%）。2010 年 4 月，所有样本中育龄女性低 RBC 叶酸水平的患病率为 0.16%。血清叶酸平均水平增加了 31%（从 17.7 nmol/L 增至 23.1 nmol/L；t=9.3，P<0.01），RBC 叶酸平均水平增加了 22%（从 881 nmol/L 增至 1071 nmol/L）。血清叶酸平均水平的最大增长发生在 2009 年 9 月，即强制添加叶酸的月份，但在此之前的几个月中就已经有了逐渐变化的迹象。
强制在小麦粉中添加叶酸显著降低了澳大利亚叶酸缺乏症的患病率，包括育龄妇女。
