Department of Environmental Sciences, University of Tuscia, Largo dell'Università, snc, 01100 Viterbo, Italy.
J Proteomics. 2011 Nov 18;74(12):2575-95. doi: 10.1016/j.jprot.2011.01.001. Epub 2011 Jan 15.
As alterations of the redox homeostasis lie at the root of many pathophysiological processes in human health, redox proteomics holds the promise to shed further light on fundamental biological processes. In this review, the mechanisms of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production are reviewed, mainly addressing those chemical phenomena which have already been associated with pathological conditions (of the central nervous system, cardiovascular system, or simply related to aging and altered-cell cycle regulation). From Alzheimer's to Parkinson's and Hungtinton's disease, from ageing to cancer, oxidative stress (OS) appears to represent a common trait in so many relevant biological aspects of human health, that further investments in the field of redox proteomics ought to be mandatory. For the foreseeable future, redox proteomics will likely play a pivotal role in the quest for new therapeutical targets and their validation, in the process of determining OS-triggered cellular alteration upon drug treatments and thus in the very heart of the design and testing of new drugs and their metabolites against those pathologies relying on altered redox homeostasis.
由于氧化还原平衡的改变是许多人类健康病理生理过程的根源，因此氧化还原蛋白质组学有望进一步揭示基本的生物学过程。在这篇综述中，我们回顾了活性氧（ROS）和活性氮（RNS）产生的机制，主要涉及已经与病理状况（中枢神经系统、心血管系统或与衰老和细胞周期调节改变有关的疾病）相关的那些化学现象。从阿尔茨海默病到帕金森病和亨廷顿病，从衰老到癌症，氧化应激（OS）似乎是人类健康许多相关生物学方面的共同特征，因此在氧化还原蛋白质组学领域进一步投资是必要的。在可预见的未来，氧化还原蛋白质组学可能在寻求新的治疗靶点及其验证方面发挥关键作用，在确定药物治疗引起的 OS 触发的细胞改变过程中，以及在设计和测试新药物及其代谢物以对抗依赖于改变的氧化还原平衡的这些疾病方面发挥关键作用。
