Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Virology. 2011 Mar 15;411(2):244-50. doi: 10.1016/j.virol.2010.12.024. Epub 2011 Jan 15.
The final assembly of nonlytic envelope viruses requires the coordinated transport of either subviral particles or fully formed virions to the plasma membrane for release from the cell. Recent research has delved into the mechanisms viruses employ to hijack the host cell's cytoskeletal system for active transport to the site of final assembly and release. This review will look at recent findings that relate to the transport of virions to the cell periphery and out of the cell.
非裂解包膜病毒的最终组装需要亚病毒颗粒或完全形成的病毒粒子的协调运输,以便从细胞中释放到质膜。最近的研究深入探讨了病毒劫持宿主细胞的细胞骨架系统进行主动运输到最终组装和释放部位的机制。本文综述了与病毒向细胞边缘和细胞外运输相关的最新发现。