Department of Internal Medicine, Division of Cardiovascular Medicine, University of California-Davis, CA, USA.
J Atheroscler Thromb. 2011;18(4):318-27. doi: 10.5551/jat.6114. Epub 2011 Jan 13.
A pro-thrombotic, pro-inflammatory diet can play a causative role in atherosclerotic-cardiovascular diseases. Dietary intervention studies provide insight into their pathophysiological manifestations and opportunities for prevention and management. We previously showed in an acute-meal setting that a beverage containing polyphenolic- and antioxidant-rich strawberry (Fragaria) vs placebo attenuated postprandial (fed-state) increases in biomarkers of oxidative and inflammatory stress, and insulin concentrations, induced by a high carbohydrate/fat (HCF) meal. In the present study, we aimed to extend our findings and investigate hypotheses related to the effects of chronic/6-week (wk) strawberry consumption on HCF meal-induced increases in glucose, insulin, and indicators of inflammation and hemostasis.
In a crossover design, 14 women and 10 men (mean age, BMI: 50.9±15 years, 29.2±2.3 kg/m(2), respectively), were randomized to a 6-wk strawberry or placebo beverage followed by an HCF meal with assessments for 6-hours (h) postprandially.
HCF meal responses after 6-wk strawberry beverage showed significantly attenuated postprandial PAI-1 concentrations compared to the placebo (p =0.002); the difference was most notable at 6 h. The IL-1 β response was attenuated with strawberry compared to the placebo (p =0.05). IL-6 attenuation was apparent but non-significant; IL-6 rose significantly from baseline to 6 h after the HCF meal following a placebo (p ≤0.01), although it remained relatively flat following the strawberry beverage from fasting to 6 h. No significant treatment-related differences were apparent for platelet aggregation, hsCRP, TNF-α, insulin, or glucose.
These data are the first to suggest that regular consumption of strawberry, a polyphenolic- and antioxidant-rich fruit, may provide protection from HCF meal-induced increases in fibrinolytic and inflammatory factors in at-risk men and women.
促血栓形成、促炎饮食可能在动脉粥样硬化性心血管疾病中起因果作用。饮食干预研究提供了洞察其病理生理表现以及预防和管理的机会。我们之前在急性膳食环境中表明，一种含有多酚和抗氧化剂丰富的草莓（Fragaria）的饮料与安慰剂相比，可减轻高碳水化合物/脂肪（HCF）膳食引起的餐后（进食状态）生物标志物氧化和炎症应激以及胰岛素浓度的增加。在本研究中，我们旨在扩展我们的发现，并研究与慢性/6 周（wk）草莓消耗对 HCF 膳食诱导的葡萄糖、胰岛素和炎症及止血标志物增加相关的假设。
采用交叉设计，14 名女性和 10 名男性（平均年龄，BMI：50.9±15 岁，29.2±2.3kg/m2），随机分为 6 周草莓或安慰剂饮料组，然后进行 HCF 膳食，在餐后 6 小时（h）进行评估。
与安慰剂相比，6 周草莓饮料后 HCF 膳食反应的 PAI-1 浓度明显降低（p =0.002）；差异在 6 小时时最为显著。与安慰剂相比，草莓组的 IL-1β反应减弱（p =0.05）。IL-6 衰减明显但不显著；IL-6 在 HCF 餐后从基线显著升高至 6 小时（p≤0.01），而在服用草莓饮料后，从空腹至 6 小时相对平稳。血小板聚集、hsCRP、TNF-α、胰岛素或葡萄糖无明显治疗相关差异。
这些数据首次表明，经常食用富含多酚和抗氧化剂的草莓可能为高危男性和女性提供保护，防止 HCF 膳食引起的纤维蛋白溶解和炎症因子增加。
