Oral Surgery and Implant Dentistry Department, School of Dentistry, University of Granada, Granada, Spain.
Clin Oral Implants Res. 2011 Aug;22(8):857-64. doi: 10.1111/j.1600-0501.2010.02073.x. Epub 2011 Jan 18.
Maxillary sinus augmentation is a predictable implant site development technique, although several local and systemic factors may influence outcomes. The aim of this study was to evaluate healing patterns and bone remodeling activity following the use of two different graft mixtures for maxillary sinus augmentation.
Patients in need of maxillary sinus augmentation were randomly assigned to two different groups. A graft mixture using a 50% autologous bone (AB) to 50% anorganic bovine bone (ABB) ratio was used in group 1, while a 20% AB to 80% ABB ratio was utilized for group 2. After a 6-month healing period, bone core biopsies were harvested for histological, histomorphometrical, and immunohistochemical analyses.
Twenty-eight subjects participated in this study. No statistically significant differences were found between groups in regards to vital bone and non-mineralized tissue proportions. Higher number of osteoid lines (18.05 ± 10.06 in group 1 vs. 9.01 ± 7.53 in group 2; P = 0.023) and higher cellularity, particularly regarding the number of osteocytes (631.85 ± 607.98 in group 1 vs. 219.08 ± 103.26 in group 2; P = 0.002), were observed in specimens from group 1. Differences in expression patterns of osteopontin and tartrate-resistant acid phosphatase were also detected between groups.
AB to ABB ratio appears to influence bone remodeling patterns and cell content following maxillary sinus augmentation procedures. Similar proportion of vital bone was found in specimens obtained from both groups. More cellular presence was observed in samples containing higher proportions of AB.
上颌窦提升是一种可预测的种植体部位开发技术，但有几个局部和全身因素可能会影响结果。本研究的目的是评估两种不同的移植物混合物在上颌窦提升后愈合模式和骨重塑活性。
需要上颌窦提升的患者被随机分配到两组。一组使用 50%自体骨（AB）和 50%无机牛骨（ABB）的混合物，另一组使用 20% AB 和 80% ABB 的混合物。在 6 个月的愈合期后，采集骨芯活检进行组织学、组织形态计量学和免疫组织化学分析。
28 名受试者参加了这项研究。两组在有活力的骨和非矿化组织比例方面无统计学差异。组 1 的类骨质线数量（18.05±10.06）高于组 2（9.01±7.53；P=0.023），细胞数量更高，特别是骨细胞数量（组 1 为 631.85±607.98，组 2 为 219.08±103.26；P=0.002）。组 1 标本中还检测到骨桥蛋白和抗酒石酸酸性磷酸酶表达模式的差异。
AB 与 ABB 的比例似乎会影响上颌窦提升术后的骨重塑模式和细胞含量。两组获得的标本中有相似比例的有活力的骨。含有较高 AB 比例的样本中观察到更多的细胞存在。
