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胚胎干细胞:在临床治疗中有用吗?

Embryonic stem cells: are useful in clinic treatments?

机构信息

Institute of Life Sciences, Catholic University of Valencia, Valencia, Spain.

出版信息

J Physiol Biochem. 2011 Mar;67(1):141-4. doi: 10.1007/s13105-010-0064-0. Epub 2011 Jan 19.

DOI:10.1007/s13105-010-0064-0
PMID:21246421
Abstract

It is not uncommon to find statements in the social media and even in some scientific journals declaring that embryonic stem cells can be used in human medicine for therapeutic purposes. In our opinion, this statement does not fit the medical reality. To go into this subject in depth, and if possible to clarify it, we reviewed the most recent literature on clinical trials conducted with embryonic stem cells, concluding that up to the present time, there is only one ongoing clinical trial being carried out with these types of cells to treat a small group of patients with spinal cord injury. The results of this trial have still not been published. In conclusion, at present, there is only evidence of one phase I clinical trial conducted with embryonic stem cells, in comparison to the numerous trials conducted with adult stem cells.

摘要

在社交媒体上,甚至在一些科学期刊中,都不难发现声称胚胎干细胞可用于人类医学治疗目的的言论。在我们看来,这种说法不符合医学现实。为了深入探讨这个问题,如果可能的话,澄清这个问题,我们查阅了关于使用胚胎干细胞进行临床试验的最新文献,得出的结论是,迄今为止,只有一项正在进行的临床试验使用这些类型的细胞来治疗一小群脊髓损伤患者。该试验的结果尚未公布。总之,目前只有一项使用胚胎干细胞进行的 I 期临床试验的证据,而相比之下,大量的临床试验都是使用成人干细胞进行的。

相似文献

1
Embryonic stem cells: are useful in clinic treatments?胚胎干细胞:在临床治疗中有用吗?
J Physiol Biochem. 2011 Mar;67(1):141-4. doi: 10.1007/s13105-010-0064-0. Epub 2011 Jan 19.
2
Good practice.良好做法。
Nature. 2014 Jun 12;510(7504):187-8. doi: 10.1038/510187b.
3
Caution urged in trial of stem cells to treat spinal-cord injury.干细胞治疗脊髓损伤试验需谨慎推进。
Nature. 2009 Mar 5;458(7234):29. doi: 10.1038/458029a.
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Pluripotent Stem Cells for Spinal Cord Injury Repair.多能干细胞在脊髓损伤修复中的应用。
Cells. 2021 Nov 27;10(12):3334. doi: 10.3390/cells10123334.
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Human embryonic and induced pluripotent stem cells in clinical trials.临床试验中的人胚胎干细胞和诱导多能干细胞。
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Stem cell therapies for acute spinal cord injury in humans: a review.人类急性脊髓损伤的干细胞治疗:综述。
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GRNOPC1: the world's first embryonic stem cell-derived therapy. Interview with Jane Lebkowski.GRNOPC1:全球首款胚胎干细胞衍生疗法。专访简·勒布科夫斯基。
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Neural tissue engineering using embryonic and induced pluripotent stem cells.胚胎干细胞和诱导多能干细胞的神经组织工程。
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Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?脊髓损伤干细胞治疗的挑战:人胚胎干细胞、内源性神经干细胞还是诱导多能干细胞?
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引用本文的文献

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Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research.比较干细胞、转分化和脑类器官作为精神疾病研究工具。
Transl Psychiatry. 2024 Feb 28;14(1):127. doi: 10.1038/s41398-024-02780-8.
2
Effects of combination treatment with transcranial magnetic stimulation and bone marrow mesenchymal stem cell transplantation or Raf inhibition on spinal cord injury in rats.经颅磁刺激联合骨髓间充质干细胞移植或 Raf 抑制对大鼠脊髓损伤的影响。
Mol Med Rep. 2021 Apr;23(4). doi: 10.3892/mmr.2021.11934. Epub 2021 Mar 2.
3
Cell Therapy Augments Functional Recovery Subsequent to Spinal Cord Injury under Experimental Conditions.

本文引用的文献

1
Geron gets green light for human trial of ES cell-derived product.杰龙公司的胚胎干细胞衍生产品获人体试验许可。
Nat Biotechnol. 2009 Mar;27(3):213-4. doi: 10.1038/nbt0309-213a.
2
Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient.共济失调毛细血管扩张症患者神经干细胞移植后供体来源的脑肿瘤
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FDA scrutinizes human stem cell therapies.美国食品药品监督管理局审查人类干细胞疗法。
在实验条件下,细胞疗法可增强脊髓损伤后的功能恢复。
Stem Cells Int. 2015;2015:132172. doi: 10.1155/2015/132172. Epub 2015 Jul 9.
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Perspectives on the use of stem cells for autism treatment.关于使用干细胞治疗自闭症的观点。
Stem Cells Int. 2013;2013:262438. doi: 10.1155/2013/262438. Epub 2013 Oct 10.
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Cell transplantation for spinal cord injury: a systematic review.脊髓损伤的细胞移植:系统评价。
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Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes.1 型和 2 型糖尿病患者的无转基因疾病特异性诱导多能干细胞。
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8
Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells.由 GMP 级造血祖细胞和单核髓样细胞诱导的多能干细胞。
Stem Cell Res Ther. 2011 Nov 16;2(6):46. doi: 10.1186/scrt87.
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4
Tolerance strategies for stem-cell-based therapies.基于干细胞疗法的耐受性策略。
Nature. 2008 May 15;453(7193):330-7. doi: 10.1038/nature07041.
5
Therapeutic cloning in individual parkinsonian mice.针对个别帕金森病小鼠的治疗性克隆
Nat Med. 2008 Apr;14(4):379-81. doi: 10.1038/nm1732. Epub 2008 Mar 23.
6
Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases.血液来源和骨髓来源干细胞在非恶性疾病中的临床应用。
JAMA. 2008 Feb 27;299(8):925-36. doi: 10.1001/jama.299.8.925.
7
Derive and conquer: sourcing and differentiating stem cells for therapeutic applications.获取并攻克:获取用于治疗用途的干细胞并加以区分。
Nat Rev Drug Discov. 2008 Feb;7(2):131-42. doi: 10.1038/nrd2403.
8
Treating diseases with adult stem cells.用成体干细胞治疗疾病。
Science. 2007 Jan 19;315(5810):328. doi: 10.1126/science.315.5810.328b.
9
Biomedicine. Selling the stem cell dream.生物医学。兜售干细胞梦想。
Science. 2006 Jul 14;313(5784):160-3. doi: 10.1126/science.313.5784.160.