Can Fam Physician. 1989 Oct;35:2115-8.
Influenza causes significant morbidity and mortality in Canada yearly despite the availability of vaccine and the antiviral drug amantadine (Symmetrel®). Vaccine is prepared annually against specific subtypes of influenza A and B that are anticipated to predominate during the winter months. The vaccine should be given in early autumn to patients considered at high risk for the sequelae of influenza. Amantadine, which was first marketed for the treatment of influenza in the early 1960s, is effective in the prevention and early treatment of illness caused by influenza A and is ineffective against influenza B. The drug is available in oral form and should be used as an adjunct to immunization or as an alternative in those for whom immunization is contraindicated or ineffective.
流感每年都会在加拿大造成大量的发病率和死亡率，尽管有疫苗和抗病毒药物金刚烷胺（Symmetrel®）可用。疫苗是每年针对预计在冬季流行的特定甲型和乙型流感亚型制备的。应在初秋向被认为有流感后遗症高风险的患者给予疫苗。金刚烷胺于 20 世纪 60 年代初首次上市用于治疗流感，对预防和早期治疗甲型流感引起的疾病有效，对乙型流感无效。该药物有口服剂型，应作为免疫接种的辅助手段，或在免疫接种禁忌或无效的情况下替代使用。
