人体血浆中内皮素的浓度：动静脉差异及静脉淤滞期间的释放情况。

Plasma concentrations of endothelin in man: arterio-venous differences and release during venous stasis.

作者信息

Wagner O F, Nowotny P, Vierhapper H, Waldhäusl W

机构信息

I Medizinische Universitätsklinik, Division of Clinical Endocrinology and Diabetes Mellitus, Vienna, Austria.

出版信息

Eur J Clin Invest. 1990 Oct;20(5):502-5. doi: 10.1111/j.1365-2362.1990.tb01892.x.

DOI:10.1111/j.1365-2362.1990.tb01892.x

PMID:2124980

Abstract

Endothelin-1 is a recently described endothelium-derived vasoconstricting peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in six healthy young men applying a radioimmunoassay after extraction of endothelin from plasma. In venous plasma a mean concentration of 1.3 +/- 0.4 pmol l-1 was found, whereas the mean concentration in arterial plasma was 0.9 +/- 0.4 pmol l-1 (P less than 0.005). During venous stasis for 10 min the mean plasma concentration of IR-endothelin increased about twofold, from basal 1.1 +/- 0.3 pmol l-1 to 2.1 +/- 0.3 pmol l-1 (P less than 0.01). This manoeuvre may prove helpful to investigate the control of endothelin in vivo under a variety of pathological conditions.

摘要

内皮素-1是最近发现的一种由内皮细胞产生的血管收缩肽。应用放射免疫分析法，在从血浆中提取内皮素后，对6名健康年轻男性的免疫反应性（IR-）内皮素的血浆浓度进行了研究。静脉血浆中发现的平均浓度为1.3±0.4 pmol l-1，而动脉血浆中的平均浓度为0.9±0.4 pmol l-1（P<0.005）。在静脉淤滞10分钟期间，IR-内皮素的平均血浆浓度增加了约两倍，从基础值1.1±0.3 pmol l-1增至2.1±0.3 pmol l-1（P<0.01）。这一操作可能有助于研究在各种病理条件下体内内皮素的调控情况。